Accidental awareness while under general anaesthesia.

Accidental awareness while under general anaesthesia. Biosci Trends. 2019;13(4):364-366 Authors: Chang L, Luo Q, Chai Y, Shu H Abstract Accidental awareness during general anaesthesia may cause many intraoperative discomforts and bring further moderate to severe long-term symptoms including flashbacks, nightmares, hyperarousal or post-traumatic stress disorder. The incidence of awareness varied from 0.017% to 4% among studies. The relatively reliable incidence of intraoperative awareness with postoperative recall is 0.02%. The reason causing awareness was unclear. Insufficient anaesthetic dosing was thought as the principal cause. Even awareness was not comprehensively understood, some endeavors have been raised to prevent or reduce it, including i) Reducing the insufficient anaesthetic dosing induced by negligence; ii) Providing close clinical observation and clinical parameters from the monitor such as bispectral index or electroencephalogram, as well as isolated forearm technique and passive brain-computer interface may bring some effects sometimes. Because current studies still have some flaws, further trials with new detecting approach, superior methodology and underlying aetiology are needed to unfasten the possible factors causing awareness. PMID: 31527334 [PubMed - in process]
Source: BioScience Trends - Category: Biomedical Science Tags: Biosci Trends Source Type: research

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ConclusionResearch on postoperative traumatic stress, including PTSD, is in its infancy. Current evidence shows elevated incidence rates of postoperative traumatic stress, which can worsen overall physical and mental health outcomes. Future research on assessment, prevention, and treatment is warranted.
Source: Canadian Journal of Anesthesia - Category: Anesthesiology Source Type: research
ConclusionRepeated intake of caffeine aggravates PTSD-like symptoms in stress-exposed rats and induces PTSD-like symptoms in unstressed rats by altering the expression of glucocorticoid receptors.Graphical abstract
Source: Physiology and Behavior - Category: Physiology Source Type: research
DiscussionMOTANA is an exploratory study aimed at designing an innovative BCI based on EEG-motor brain activity that would detect an attempt to move by a patient under anesthesia. This would be of interest in the prevention of AAGA.Trial registrationAgence Nationale de S écurité du Médicament (EUDRACT 2017-004198-1), NCT03362775. Registered on 29 August 2018.https://clinicaltrials.gov/ct2/show/NCT03362775?term=03362775&rank=1
Source: Trials - Category: Research Source Type: clinical trials
In this study, we investigated the temporal effects of electroacupuncture (EA) at acupoint ST36 on anxiety-like behaviors and the expression of c-Fos in the anterior cingulate cortex (ACC) in a rat model of PTSD. PTSD was induced by a single prolonged stress procedure comprising three stages: restraint for 2 h, forced swim for 20 min, and pentobarbital sodium anesthesia. EA at acupoint ST36 was performed from 7:00-9:00 once a day for 7 consecutive days. Open field test (OFT) and elevated plus maze (EPM) test were used to assess the success of the model and evaluate anxiety-like behaviors. Immunohistochemistry...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Sir, we wish to report an unusual accidental bite injury of the lower lip following administration of local anaesthetic. A 21-year-old gentleman presented to the Accident and Emergency department having bitten the left lower lip. This occurred shortly a...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Several lines of evidences show that anesthetics influence neurotoxicity and neuroprotection. The possibility that different anesthetic agents potentially influence the pathophysiological and functional outcome following neurotrauma was examined in a rat m...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
ConclusionThe surgeons agree with the statement that success in the preventing reankylosis after TMJ gap arthroplasty. Its primarily refers to the early postoperative physiotherapy, maintained on a long term.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
The objective of this study was to assess clinical and radiological outcomes and morbidity (complications and revisions) in 6 patients managed with S1-TKA-FO.Hypothesis1S-TKA-FO produces satisfactory outcomes and is not associated with higher morbidity rates compared to two-stage TKA-TO or TKA with intra-articular EKD correction, while also significantly shortening total treatment duration.Material and methodsA prospective study was performed in 6 patients managed with 1S-TKA-FO between 1999 and 2011; mean age was 64 years (range, 59–72 years) and mean body mass index was 29.5 (range, 26–35). The EKD was consis...
Source: Orthopaedics and Traumatology: Surgery and Research - Category: Orthopaedics Source Type: research
Ketamine, a dissociative anesthetic, is effective in reducing psychiatric distress in individuals with major depression (MDD) and posttraumatic stress disorder (PTSD). However, the effect of ketamine administration on cognition in these disorders has not been directly investigated. The present study sought to address this area by exploring the effect of ketamine administration on a battery of cognitive tests in individuals with MDD, PTSD, and age and sex matched healthy controls.
Source: Biological Psychiatry - Category: Psychiatry Authors: Source Type: research
AbstractPurposePosttraumatic stress disorder (PTSD) is a debilitating psychiatric disorder with a lifetime prevalence of 6.1% in the general adult population. Clinical guidelines for the treatment of PTSD suggest the use of trauma-focused psychotherapies such as prolonged exposure (PE) and cognitive-behavioral therapy (CBT). As a second-level intervention, these guidelines suggest the use of psychotropic medications, mainly selective serotonin reuptake inhibitors (SSRIs). To date, however, studies have shown that both psychotherapeutic and psychopharmacologic treatments have limited efficacy, with remission rates around 40...
Source: Current Treatment Options in Psychiatry - Category: Psychiatry Source Type: research
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