Impact of yoga based lifestyle intervention on quality of life, depression and sperm oxidative DNA damage: a randomized controlled trial on infertile men with rheumatoid arthritis

Rheumatoid arthritis (RA), an auto-immune disease, shows a consecutive stimulus of proinflammatory cytokines, following a wide range of pathophysiological reactions, leading to increased synthesis of acute phase proteins like C - reactive protein (CRP) and dysregulation in levels of immunomodulatory soluble Human Leukocyte Antigen-G (sHLA-G) molecule. Toxic effects of Methotrexate (MTX), a major component of disease-modifying antirheumatic drugs (DMARDs), can cross blood-testis-barrier and can induce changes in sperm for men of reproductive age group like germ cell apoptosis, mutagenic changes in germline cells, permanent gonadal failure and impaired spermatogenesis.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research