Induction of spermatogenesis under 3-dimentional tissue culture conditions by in vitro transplantation of spermatogonial stem cells isolated from human frozen-thawed testis tissue

In this study, we examine the progression of spermatogenesis after transplantation of spermatogonial stem cells under conditions of testicular tissue culture.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research

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ConclusionsThis meta-analysis reflects low pregnancy rates for cancer survivors desiring a family. However, live births are improving over time with new technology and novel therapies. Hence, female cancer patients should be offered timely discussions, counselling and education around fertility preservation options prior to starting treatment with gonadotoxic therapy.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
In this study, the enhanced mice live somewhat longer than their unmodified peers, though not as much longer as is the case for the application of telomerase gene therapy. The mice do also exhibit reduced cancer risk, however. The scientists here class telomere shortening as a cause of aging, which is not a point universally agreed upon. Reductions in average telomere length in tissues looks much more like a downstream consequence of reduced stem cell activity than an independent mechanism. Researchers obtain the first mice born with hyper-long telomeres and show that it is possible to extend life without any geneti...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Vermeulen M, Giudice MG, Del Vento F, Wyns C Abstract While improvements made in the field of cancer therapy allow high survival rates, gonadotoxicity of chemo- and radiotherapy can lead to infertility in male and female pre- and postpubertal patients. Clinical options to preserve fertility before starting gonadotoxic therapies by cryopreserving sperm or oocytes for future use with assisted reproductive technology (ART) are now applied worldwide. Cryopreservation of pre- and postpubertal ovarian tissue containing primordial follicles, though still considered experimental, has already led to the birth of he...
Source: Stem Cells and Cloning: Advances and Applications - Category: Stem Cells Tags: Stem Cells Cloning Source Type: research
Primary ovarian insufficiency (POI) refers to ovarian loss of function under the age of 40 years and lead those patients to usually present by amenorrhea and infertility. One of the reasons of POI is chemotherapy for cancer patients. It is broadly believed that chemotherapy drugs may vastly eliminate granulosa cells which are essential for oocyte survival and follicular development. Our previous study shows that transplantation of human bone marrow derived mesenchymal stem cell (hBM-MSC) in chemotherapy induced POI mouse ovary can reverse POI through correction of serum hormonal level, promote follicular generation in ovar...
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Poster session Source Type: research
There is nothing more frustrating than when the cure is part of the problem. Because depression is prevalent in patients with physical disorders like cancer, stroke, and heart disease, medications often interact with each other, complicating treatment. To appropriately manage depression, you and your physician need to evaluate all medications involved and make sure they aren’t cancelling each other out. A review in the journal Dialogues in Clinical Neuroscience a while back highlighted certain medications that can cause depression. The following are medications to watch out for. Medications to Treat Seizures and Park...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Depression Medications Drug Interactions Mood Disorder Source Type: blogs
(Abstracted from Hum Reprod 2018;33:2249–2255) Cytotoxic cancer treatments, including chemotherapy and radiotherapy, cause damage to spermatogenic stem cells (SSCs), jeopardizing the fertility of young men of reproductive age. One potential method for future production of sperm in this population is SSC transplantation.
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: GYNECOLOGY: INFERTILITY/REPRODUCTIVE TECHNOLOGIES Source Type: research
When Noah Shulman was born a few days after Christmas 2016, his parents Kristelle and Evan had no reason to worry about him. The pregnancy went smoothly, and so did the birth. But within a few days of taking his first breath, Noah began to struggle. He wasn’t feeding, so he started losing weight. He was also lethargic. Several pediatricians reassured the Shulmans that they were probably just overly sensitive to Noah’s symptoms because Kristelle is a nurse and Evan is a physician assistant–a case of first-time-parent-white-coat syndrome. “They kind of dismissed us as neurotic parents,” says Eva...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized fertility Research Source Type: news
Stem cells survive oncotherapy &can regenerate non-functional gonads: A paradigm shift for oncofertility. Indian J Med Res. 2018 Dec;148(Supplement):S38-S49 Authors: Bhartiya D Abstract A large proportion of patients who survive cancer are rendered infertile as an unwanted side effect of oncotherapy. Currently accepted approaches for fertility preservation involve banking eggs/sperm/embryos or ovarian/testicular tissue before oncotherapy for future use. Such approaches are invasive, expensive, technically challenging and depend on assisted reproductive technologies (ART). Establishing a gonadal ti...
Source: The Indian Journal of Medical Research - Category: Biomedical Science Authors: Tags: Indian J Med Res Source Type: research
Publication date: Available online 3 November 2018Source: Best Practice &Research Clinical Endocrinology &MetabolismAuthor(s): Marc Kanbar, Francesca di Michele, Christine WynsAbstractTransplantation of own cryostored spermatogonial stem cells (SSCs) is a promising technique for fertility restoration when the SSC pool has been depleted.In this regard, cryopreservation of pre-pubertal testicular tissue or SSCs suspensions before gonadotoxic therapies is ethically accepted and increasingly proposed.SSC transplantation has also been considered to treat other causes of infertility relying on the possibility of propagat...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - Category: Endocrinology Source Type: research
Fanconi anemia (FA) is a relatively rare genetic condition with primary sequelae of bone marrow failure, hematologic malignancies, and squamous cell cancers (SCC) of head/neck, breast, and anogenital tract. Many patients require hematopoietic stem cell transplant (bone marrow transplant, BMT) to treat marrow dysfunction, but risk of future malignancies remains. Female patients are at risk of reproductive complications, including infertility related to primary ovarian insufficiency (POI) and gynecologic cancers.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
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