Long-term outcomes of childhood sexual abuse: an umbrella review

This study is registered with PROSPERO, CRD42016049701.FindingsWe identified 19 meta-analyses that included 559 primary studies, covering 28 outcomes in 4 089 547 participants. Childhood sexual abuse was associated with 26 of 28 specific outcomes: specifically, six of eight adult psychiatric diagnoses (ORs ranged from 2·2 [95% CI 1·8–2·8] to 3·3 [2·2–4·8]), all studied negative psychosocial outcomes (ORs ranged from 1·2 [1·1–1·4] to 3·4 [2·3–4·8]), and all physical health conditions (ORs ranged from 1·4 [1·3–1·6] to 1·9 [1·4–2·8]). Strongest psychiatric associations with childhood sexual abuse were reported for conversion disorder (OR 3·3 [95% CI 2·2–4·8]), borderline personality disorder (2·9 [2·5–3·3]), anxiety (2·7 [2·5–2·8]), and depression (2·7 [2·4–3·0]). The systematic reviews for two psychiatric outcomes (post-traumatic stress disorder and schizophrenia) and one psychosocial outcome (substance misuse) met high quality standards. Quality was low for meta-analyses on borderline personality disorder and anxiety, and moderate for conversion disorder. Assuming causality, population attributable risk fractions for outcomes ranged from 1·7% (95% CI 0·7–3·3) for unprotected sexual...
Source: The Lancet Psychiatry - Category: Psychiatry Source Type: research

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ConclusionIn our study, the Met-allele was associated with higher stress levels. To the best of our knowledge, this is the first study investigating this area. The findings from this study should trigger more investigators to focus on the impact of stress, due to the potential effects of these genes, on medical students.
Source: Journal of Taibah University Medical Sciences - Category: Universities & Medical Training Source Type: research
In an attempt to keep the main University of Michigan thread on topic and avoid the spamming that we saw last week, I have made this thread for all of our neuroticism and anxiety to be redirected to. I will lock this thread Monday evening and I will unlock it the following Sunday. @EmbryonalCarcinoma @Doctors' Docta @pagingdocopp @Jappa @peanutbuttah @premedpower8484848... Round 14 - 2019-2020 #UMichMedMonday thread
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pre-Medical - MD Source Type: forums
ConclusionsAlpha-synchronized rTMS of left DLPFC is feasible, safe and has specific single-session neuromodulatory effects in patients with antidepressant-resistant MDD. Future studies need to further elucidate the mechanisms, optimize the parameters and investigate the therapeutic potential and efficacy of brain oscillation-synchronized rTMS in MDD.
Source: Brain Stimulation - Category: Neurology Source Type: research
João A. P. Coutinho It was recently shown that tetramethylammonium chloride presented negative deviations to ideality when mixed with tetraethylammonium chloride or tetrapropylammonium chloride, leading to a strong decrease of the melting points of these salt mixtures, in a behavior akin to that observed in the formation of deep eutectic solvents. To better rationalize this unexpected melting point depression between two structurally similar compounds devoid of dominant hydrogen bonding capability, new solid–liquid equilibria data for tetramethylammonium-based systems were measured and analyzed in this...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Publication date: Available online 12 October 2019Source: Journal of Psychiatric ResearchAuthor(s): Patrick J.F. Clarke, Brodie F. Sprlyan, Colette R. Hirsch, Frances Meeten, Lies NotebaertAbstractWhile considerable experimental research has examined the impact of transcranial direct current stimulation (tDCS) on a range of cognitive processes associated with emotional pathology, the impact of tDCS on worry has been comparatively neglected. Given that anxiety pathology is characterised by motivated engagement in worry, and that frontal tDCS has the capacity to enhance goal-oriented cognition, it is important to examine whe...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
ConclusionsWhen considered within the context of previous research, the experimental effects and therapeutic potential of CBM-I for high AS appear to be minimal. However, methodological questions need to be resolved before such a conclusion can be considered definitive.
Source: Journal of Behavior Therapy and Experimental Psychiatry - Category: Psychiatry Source Type: research
Publication date: Available online 10 October 2019Source: NeuroImageAuthor(s): Spurny B, Seiger R, Moser P, Vanicek T, M.B. Reed, Heckova E, Michenthaler P, Basaran A, Gryglewski G, Klöbl M, Trattnig S, Kasper S, Bogner W, Lanzenberger RAbstractNeural plasticity is a complex process dependent on neurochemical underpinnings. Next to the glutamatergic system which contributes to memory formation via long-term potentiation (LTP) and long-term depression (LTD), the main inhibitory neurotransmitter, GABA is crucially involved in neuroplastic processes. Hence, we investigated changes in glutamate and GABA levels in the brai...
Source: NeuroImage - Category: Neuroscience Source Type: research
Conclusion It is clear that clinically, there is still much to be learnt about alexithymia and its relationship with a range of related phenomena. Firstly, is alexithymia a continuous and stable trait independent of psychological or somatic symptomology that is developed during childhood? Or is it instead a reactive state induced by trauma and distress at any age, which serves to defend against intense and upsetting emotions? This impacts on treatment options. For example, should we be focussing on early childhood interventions which target the child's emotional environment and parenting to encourage emotional exp...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
 Growing up with a mentally ill parent can be a traumatic experience for any child. For Ally Golden, her mother’s mental illness was major depression, later diagnosed as borderline personality disorder. Ally’s book, A Good Soldier, chronicles her life growing up in this environment, with a mentally ill mother who frequently threatened suicide, and the psychological trauma that resulted for her. Decades later, her mother carried out her threat. Listen to hear Ally’s fascinating story. Subscribe to Our Show! And Remember to Review Us! About Our Guest Ally Golden is the author ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Borderline Personality General Relationships The Psych Central Show Gabe Howard Suicide Vincent M. Wales Source Type: blogs
We present clinical and outcome data on an initial sample of patients treated over the last 5 years.MethodsNaturalistic, non-controlled assessment of symptomatic and functional outcome in an initial sample of young adults with persistent mental illnesses treated in a community-based residential program. Patients were treated with an individualized combination of modalities such as Illness Education and Management, Supported Employment, Individual, Group and Family Psychotherapies and Psychopharmacology. Standard clinical rating scales were used during the period of treatment and all discharged patients were contacted on an...
Source: Schizophrenia Bulletin - Category: Psychiatry Source Type: research
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