Prognostic Value of Preoperative Pulmonary Arterial Capacitance for Patients Undergoing Aortic Valve Replacement for Severe Aortic Valve Stenosis.

CONCLUSIONS: In these patients undergoing AVR for severe AS, even in the absence of PH, preoperative reduced PAC was independently associated with adverse surgical outcomes. It seems that preoperative PAC has potential as an independent predictor of long-term prognosis after AVR for severe AS. PMID: 31484840 [PubMed - as supplied by publisher]
Source: Circulation Journal - Category: Cardiology Authors: Tags: Circ J Source Type: research

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AbstractAimsA substantial shift in the field of pulmonary hypertension (PH) is ongoing, as the previous practice of mean pulmonary arterial wedge pressure (PAWPM) is no longer supported. Instead, aiming for a better estimate of end ‐diastolic pressures (EDP), instantaneous PAWP at mid‐A‐wave (PAWPmid ‐A) or, in the absence of an A ‐wave, at 130–160 ms following QRS onset has recently been recommended. Electrocardiogram‐gated PAWP (PAWPQRS) has also been proposed. The quantitative differences as well as the diagnostic and prognostic utility of these novel PAWP measurements have not been evaluated. We ...
Source: ESC Heart Failure - Category: Cardiology Authors: Tags: Original Research Article Source Type: research
A well-validated diagnostic algorithm for heart failure with preserved ejection fraction (HFpEF) was recently developed, utilizing hemodynamic assessment by cardiac catheterization.[1] The combination of body mass index (BMI; “heavy”), hypertension, atrial fibrillation (AF), pulmonary hypertension (PH), age (“elder”), and left ventricular (LV) filling pressure, abbreviated as H2FPEF, can differentiate patients with HFpEF from those without HFpEF, with excellent accuracy.[1] Several studies have assessed the diagn ostic performance of the H2FPEF score in various populations and demonstrated the gener...
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Source Type: research
Hypoxia in utero increases the risk of pulmonary hypertension in rat offspring and is associated with vasopressin type‑2 receptor upregulation. Mol Med Rep. 2020 Nov;22(5):4173-4182 Authors: Ding H, Luo Y, Hu K, Huang H, Liu P, Xiong M, Zhu L, Yi J, Xu Y Abstract Pulmonary hypertension (PH) in newborns and adults is a disease that can lead to right heart failure and result in a shorter lifespan. PH was induced by maintaining pregnant rats in a hypoxic chamber for 4 h twice a day, from days 7‑21 of pregnancy. Hypoxia was confirmed by a decrease in the partial pressure of oxygen (PaO2)...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
ConclusionBy applying [11C]DASB and PET/CT, semiquantitative measures of SERT availability are demonstrated in the lung vasculature of patients with COPD and/or PH. COPD patients who developed PH show increased pulmonary [11C]DASB uptake compared to COPD patients without PH indicating an implication of pulmonary SERT in the development of PH in COPD patients.
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Pulmonary hypertension (PH) is a common in patients with chronic heart failure (HF). For patients who progress to end stage HF and require orthotropic heart transplant (OHT), irreversible PH is a relative contraindication as it may lead to post-operative right HF. The International Society of Heart and Lung Transplant (ISHLT) recommends that transplantation be pursued in patients with a pulmonary vascular resistance (PVR)
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: 447 Source Type: research
AbstractBackgroundChronic obstructive pulmonary disease (COPD) is a cause of ventricular dysfunction. However, in the setting of patients with heart failure undergoing left ventricular assist device (LVAD) implantation, there is a paucity of data on the association between COPD and in ‐hospital outcomes.Methods and ResultsRetrospective cohort study based on the NIS including patients ≥18 years who underwent LVAD implantation from 2011 to 2017. Multivariate regression was used to evaluate the impact of COPD on in‐hospital outcomes. A total of 25,503 patients underwent LVAD implantation, of which 13.8% also had COPD. ...
Source: Journal of Cardiac Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: ORIGINAL ARTICLE Source Type: research
HORSHAM, PA, September 30, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson announced today that the U.S. Food and Drug Administration (FDA) has approved SIMPONI ARIA® (golimumab) for patients 2 years of age and older for the treatment of active pJIA and has extended the PsA indication for this same patient population. “This latest FDA approval of SIMPONI ARIA for pediatric use in active pJIA and active PsA not only brings a new option to young patients living with these diseases but also adds to the growing body of evidence for this treatment,” said Mathai Mammen, M.D., Ph.D., Glob...
Source: Johnson and Johnson - Category: Pharmaceuticals Source Type: news
Pulmonary hypertension (PH) is characterized by pulmonary artery remodeling that can subsequently culminate in right heart failure and premature death. Emerging evidence suggests that hypoxia-inducible factor (HIF) signaling plays a fundamental and pivotal role in the pathogenesis of PH. This Review summarizes the regulation of HIF isoforms and their impact in various PH subtypes, as well as the elaborate conditional and cell-specific knockout mouse studies that brought the role of this pathway to light. We also discuss the current preclinical status of pan- and isoform-selective HIF inhibitors, and propose new research ar...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Letter by Komamura Regarding Article, "Treatment With Treprostinil and Metformin Normalizes Hyperglycemia and Improves Cardiac Function in Pulmonary Hypertension Associated With Heart Failure With Preserved Ejection Fraction". Arterioscler Thromb Vasc Biol. 2020 Oct;40(10):e273 Authors: Komamura K PMID: 32966132 [PubMed - in process]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - Category: Cardiology Authors: Tags: Arterioscler Thromb Vasc Biol Source Type: research
Assessment of jugular venous pulse has to be done in the internal jugular vein though a beginner is often tempted to use the external jugular vein. External jugular vein may be kinked and it may not reflect the true right atrial pressure. Jugular venous pressure is measured with reference to the sternal angle. The sternal angle is 5 cm above the mid right atrium in all positions. Normal internal jugular venous pulsations are not visible in the neck in the sitting position. Hence it is typically measured with 45 degrees propped up position. But if the venous pressure is elevated, measurement in sitting position is possible...
Source: Cardiophile MD - Category: Cardiology Authors: Tags: HBC abdominojugular reflux cannon waves Friedreich’s sign hepatojugular reflux Superior vena cava syndrome Source Type: blogs
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