497 FOXP3 and CTLA-4 genetic variants influence on the susceptibility and clinical course of basal cell carcinoma

The pathogenesis of basal cell carcinoma (BCC) is multifactorial and not fully elucidated. Previous studies showed, that behaviour of the tumour may be influenced by immune system and identified CD4+CD25+FoxP3+ regulatory T cells (Tregs) as a dominant immune cells in BCC microenvironment. The function and development of Tregs is regulated by FOXP3 encoding transcription factor, Forkhead box P3 (FoxP3). FoxP3 regulates transcription of many genes, including up-regulation of cytotoxic lymphocyte-associated antigen-4 gene (CTLA-4).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Melanoma and Other Skin Cancers Source Type: research