Human blood-based exposure levels of persistent organic pollutant (POP) mixtures antagonise androgen receptor transactivation and translocation.
CONCLUSION: Taken together, some combinations of POP mixtures can interfere with AR translocation. However, in the transactivation assay, these combinations did not affect gene transactivation. Other POP combinations were identified here as modulators of AR-induced gene transactivation without affecting AR translocation. Thus, to fully evaluate the effect of environmental toxins on AR signalling, both types of assays need to be applied.
PMID: 31470217 [PubMed - as supplied by publisher]
Source: Environment International - Category: Environmental Health Authors: McComb J, Mills IG, Muller M, Berntsen HF, Zimmer KE, Ropstad E, Verhaegen S, Connolly L Tags: Environ Int Source Type: research
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