Skin/Muscle Incision and Retraction Induces Evoked and Spontaneous Pain in Mice.

Conclusion: These data suggested that the mice model of SMIR demonstrated a persistent pain syndrome, including evoked pain and spontaneous pain. Clonidine and gabapentin could relieve mechanical hypersensitivity dose-dependently simultaneously. However, clonidine but not gabapentin could alleviate the spontaneous pain of SMIR in the mice model. PMID: 31467625 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/31467625?dopt=Abstract

Source: Pain Research and Management - August 31, 2019 Category: Anesthesiology Authors: Yang J, Yuan F, Ye G, Wang YJ, Wu C, Wang J, Li XY, Feng Z Tags: Pain Res Manag Source Type: research