Lipidomic Analysis Reveals Altered Fatty Acid Metabolism in the Liver of the Symptomatic Niemann –Pick, Type C1 Mouse Model

In this study, it is sought to investigate free fatty acid levels inNpc1−/− mice with focus on the polyunsaturated ω‐3 and ω‐6 fatty acids. Since fatty acids are the main constituents of numerous lipids species, a discovery based lipidomic study of liver tissue in Npc1−/− mice is also performed. To this end, alterations in fatty acid synthesis, including the ω‐3 and 6 fatty acids, are reported. Further, alterations in enzymes that regulate the synthesis of ω‐3 and 6 fatty acids are reported. Analysis of the liver lipidome reveals alterations in both storage and membrane lipids including ceramides, fatty acids, phosphatidylcholamines, phosphatidylg lycerols, phosphatidylethanolamines, sphingomyelins, and triacylglycerols inNpc1−/− mice at a late stage of disease.

Source: Proteomics - August 28, 2019 Category: Biochemistry Authors: Melissa R. Pergande, Fidel Serna ‐Perez, Sheher Banu Mohsin, Jonathon Hanek, Stephanie M. Cologna Tags: Research Article Source Type: research