Miro2 Regulates Inter-Mitochondrial Communication in the Heart and Protects Against TAC-Induced Cardiac Dysfunction.

CONCLUSIONS: Mitochondrial Miro2 expression levels regulate inter-mitochondrial communication along microtubules in adult cardiomyocytes, and degradation of Miro2 through Parkin-mediated ubiquitination contributes to impaired inter-mitochondrial communication and cardiac dysfunction during hypertrophic heart diseases.
PMID: 31455181 [PubMed - as supplied by publisher]

Source: Circulation Research - August 27, 2019 Category: Cardiology Authors: Cao Y, Xu C, Ye J, He Q, Zhang X, Jia S, Qiao X, Zhang CL, Liu R, Weng L, Liu Y, Liu LM, Zheng M Tags: Circ Res Source Type: research