Safety of Everolimus With Reduced Calcineurin Inhibitor Exposure in De Novo Kidney Transplants: An Analysis From the Randomized TRANSFORM Study

Background. The safety profiles of standard therapy versus everolimus with reduced-exposure calcineurin inhibitor (CNI) therapy using contemporary protocols in de novo kidney transplant recipients have not been compared in detail. Methods. TRANSFORM was a randomized, international trial in which de novo kidney transplant patients were randomized to everolimus with reduced-exposure CNI (N = 1014) or mycophenolic acid (MPA) with standard-exposure CNI (N = 1012), both with induction and corticosteroids. Results. Within the safety population (everolimus 1014, MPA 1012), adverse events with a suspected relation to study drug occurred in 62.9% versus 59.2% of patients given everolimus or MPA, respectively (P = 0.085). Hyperlipidemia, interstitial lung disease, peripheral edema, proteinuria, stomatitis/mouth ulceration, thrombocytopenia, and wound healing complications were more frequent with everolimus, whereas diarrhea, nausea, vomiting, leukopenia, tremor, and insomnia were more frequent in the MPA group. The incidence of viral infections (17.2% versus 29.2%; P
Source: Transplantation - Category: Transplant Surgery Tags: Original Clinical Science—General Source Type: research

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مقدمه: ترومبوسیتوپنی ایمونولوژیک (Immune thrombocytopenia) به واسطه واکنش خودایمنی بر علیه پلاکت و تخریب آن  شناخته می شود. تظاهرات در بیماران علامت دار شامل کبودی و خونریزی های متعدد ناشی از کاهش پلاکت می باشد. گزارشمورد: بیمارمردی 75سالهباشکایتعدم امکان استفاده از دست دندا ن قدیمی خود  از ده روز قبل، به بخش بیماری های دهان، فکوصورتدانشکده دندانپزشکیم...
Source: Journal of Mashhad Dental School - Category: Dentistry Source Type: research
CONCLUSION: Patients are at a high risk of EMS-ED after dialysis initiation. Frailty severity (at the time of dialysis initiation) is a strong predictor of first and recurrent EMS-ED and this may be important to guide informed decision making and resource planning for dialysis patients who require EMS. PMID: 31800335 [PubMed - as supplied by publisher]
Source: Prehospital Emergency Care - Category: Endocrinology Tags: Prehosp Emerg Care Source Type: research
Expertise in congenital heart disease care was associated with improved outcomes for CHD patients listed for transplantation. Experience in acquired heart disease transplant may not be enough.Medscape Medical News
Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Cardiology News Source Type: news
We present a case of CAA-ri in a subject already on immunosuppressive therapy after orthotopic heart transplantation (OHT). A 57-year-old man 8 months post-OHT for sarcoid cardiomyopathy developed headaches and staring spells while hospitalized for disseminated mycobacterial infection. His brain MRI revealed bi-hemispheric T2-weighted fluid-attenuated inversion recovery white matter hyperintensities and widespread microhemorrhages. Two weeks later, he developed gait ataxia and alterations in mental status, and repeat brain MRI showed more extensive confluent white matter hyperintensities. Leptomeningeal and cortex biopsy r...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
AbstractThis observational study aimed to evaluate the prognostic significance of interim and final18F-fluorodeoxyglucose positron emission tomography-computed tomography (PET/CT) responses to upfront autologous stem cell transplantation (ASCT) in patients with peripheral T cell lymphomas (PTCLs). A total of 118 patients, from two independent institutions, with newly diagnosed PTCLs were enrolled, and 96 of them were evaluated. PET/CT was assessed at diagnosis, and during and after the primary treatment. Clinical outcomes of interim and final PET/CT were compared between transplanted and non-transplanted patients. The resp...
Source: Annals of Hematology - Category: Hematology Source Type: research
Researchers have made considerable progress in the construction of small, functional tissue sections called organoids over the past decade, enabled by a combination of better understanding the mechanisms involved in regeneration and embryonic development of tissues, advances in 3-D bioprinting, guidance of cell behavior via appropriate provision of signal molecules, and the generation of environments that mimic an existing tissue environment. Every tissue requires its own specific recipe of signals and environment in order to form a functional organoid, but researchers have demonstrated the manufacture of organoids for liv...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Authors: Itano J, Higo H, Ohashi K, Makimoto G, Nishii K, Hotta K, Miyahara N, Maeda Y, Kiura K Abstract Osimertinib is the standard therapy for epidermal-growth-factor-receptor (EGFR)-mutant lung cancers. We herein report a case of osimertinib-induced interstitial lung disease (OsiILD) with an organizing pneumonia (OP) pattern and provide a literature-based review.Six months after osimertinib administration, a 75-year-old woman with right pleural carcinomatosis developed ILD with an OP pattern. After salvage chemotherapy, osimertinib with corticosteroid was successfully re-administered. A literature review suggest...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Publication date: Available online 5 December 2019Source: American Journal of Kidney DiseasesAuthor(s): Sanjay Kulkarni, Guo Wei, Wei Jiang, Licia A. Lopez, Chirag R. Parikh, Isaac E. HallRationale &ObjectiveThere may be important transplant-related differences between right and left kidneys, including logistical/surgical considerations about vessel length for the right compared to the left kidney from the same donor. Because US centers choose between the right and left kidney when their recipient is ranked higher on a “match-run,” we sought to determine whether deceased-donor right kidneys have had worse p...
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
I once had a neighbor who was very fragile in her age. When I’d ask her how she was doing, she would always respond, “I am counting my blessings. That’s what counts. Things don’t have to be one way all the time. Changes happen and I go with them and laugh instead of growl.” I loved her attitude, even though she was ill and up in years. She was accepting changes with a positive and grateful perspective. “The greatest trap in our life is not success, popularity or power, but self-rejection.” – Henri Nouwen When we struggle with mental, emotional, physical or relationship challe...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Happiness Self-Help Coping Skills grateful Gratitude hope Inspiration Source Type: blogs
Conditions:   Post-traumatic Stress Disorder;   Insomnia Intervention:   Drug: Pimavanserin Sponsor:   Baylor College of Medicine Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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