HMPAO-SPECT can discriminate between Patients with Subjective Cognitive Complaints with and without Cognitive Deficits and those with Mild Cognitive Impairment.

CONCLUSIONS: Automated analysis of HMPAO-SPECT data of MCI and SCC+ patients showed significant perfusion differences in medial temporal region and impaired verbal memory, both of which are known features of Alzheimer's dementia. Perfusion patterns and verbal memory performance in SCC+ are more similar to MCI than SCC-. Thus, SPECT analysis could distinguish those subjects whose perfusion pattern resembles that of an MCI from those who don't. In our opinion, this could identify two populations with a different risk of progression to AD, with SCC+ subjects needing further diagnostic examination and repeated follow-up. PMID: 31453786 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31453786?dopt=Abstract

Source: Current Alzheimer Research - August 26, 2019 Category: Neurology Authors: Rossini F, Zauner H, Bergmann J, Kronbichler M, Spindler I, Golaszewski S, Trinka E, Staffen W Tags: Curr Alzheimer Res Source Type: research