Genome-Wide Profiling of Prognostic Alternative Splicing Pattern in Pancreatic Cancer

Alternative splicing (AS) has a critical role in tumor progression and prognosis. Our study aimed to investigate pancreatic cancer-specific AS events using RNA-seq data, gaining systematic insights into potential prognostic predictors. We downloaded 10623 genes with 45313 pancreatic cancer-specific AS events from the Cancer Genome Atlas (TCGA) and SpliceSeq database. Cox univariate analyses of overall survival suggested there was a remarkable association between 6711 AS events and overall survival in pancreatic cancer patients (P
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research