Intestinal Permeability and IgA Provoke Immune Vasculitis Linked to Cardiovascular Inflammation

Kawasaki disease (KD) is the leading cause of acquired heart disease among children, and the etiology is unknown. Noval Rivas et  al. demonstrate that a murine model of KD vasculitis is dependent on intestinal barrier dysfunction leading to secretory IgA leakage and IgA-C3 immune complex deposition in cardiovascular lesions.

Source: Immunity - August 26, 2019 Category: Allergy & Immunology Authors: Magali Noval Rivas, Daiko Wakita, Michael K. Franklin, Thacyana T. Carvalho, Amanda Abolhesn, Angela C. Gomez, Michael C. Fishbein, Shuang Chen, Thomas J. Lehman, Kazuki Sato, Akira Shibuya, Alessio Fasano, Hiroshi Kiyono, Masanori Abe, Narihito Tatsumoto Tags: Article Source Type: research