Ethanol Intake and A2A Receptor Overexpression

This study used a transgenic strategy, specifically rats overexpressing the A2A receptor, to characterize the neurobiological mechanisms of ethanol consumption as measured by intermittent access to 20% ethanol (IAE) in a two-bottle choice paradigm. In this model, no change in ethanol consumption was observed in transgenic animals compared to wild type controls during the acquisition/maintenance phase. Following alcohol deprivation (AD), only transgenic rats overexpressing the A2A receptor exhibited escalation of ethanol consumption and drank more (by ca. 90%), but not significantly, ethanol than did the wild type rats. During ethanol withdrawal, the immobility time of rats overexpressing the A2A receptor in the forced swim test was lower than that of wild type rats. Moreover, transgenic rats withdrawn from ethanol, compared to the drug-naive transgenic animals, exhibited an increase above 150% in locomotion. The results indicated that the overexpression of A2A receptors may be a risk factor for the escalation of ethanol consumption despite the reduction in depression-like signs of ethanol withdrawal.
Source: Neuroscience - Category: Neuroscience Source Type: research

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This study was embedded within the Irish Longitudinal Study on Ageing.Participants were a population-representative sample of almost 7,000 Irish adults aged  ≥50 years.UI was defined as any involuntary loss of urine from the bladder within the last 12 months, based on the International Continence Society Definition.QOL was measured using the Control, Autonomy, Self-realisation and Pleasure-19 Scale (CASP-19).ResultsFifteen % (1,061/6,996) of participants had UI within the last 12 months; 9% (269/3,162) of males and 21% (792/3,834) of females.Almost half (486/1,061) of participants with UI had not reported it to a...
Source: Age and Ageing - Category: Geriatrics Source Type: research
AbstractBackgroundFrailty is a common, multi-factorial, age-related syndrome commonly observed in people with diabetes. Although older diabetics are prone to adverse healthcare outcomes and diabetes increases the risk of developing frailty, little is known about the effects of frailty on diabetes. This paper examines the association between diabetes, frailty, and mortality in Europeans aged ≥50 years.MethodsData were included from The Survey of Health, Ageing and Retirement in Europe (SHARE) waves one and six. A participant ’s first interview was taken as the baseline and subsequent waves were used for mortality f...
Source: Age and Ageing - Category: Geriatrics Source Type: research
Conclusion: Specific contexts appeared to be associated with problematic drinking for both sexes. Among both men and women, "social drinking" was associated with problematic drinking. Both "home drinking" (men) and "daytime drinking" (women) contexts, were associated with problematic drinking and depressive symptoms. Targeted alcohol-focused interventions need to address co-occurring mental health issues. PMID: 31519127 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
Let’s dive into this week’s Psychology Around the Net for some perspective on how we decide to trust the news we trust, new research on a hormone we secrete when we’re panicked, a survey that shows happy people don’t just ignore the social issues around them, and more. Substance Use in the Food Service Industry: The American Addiction Centers recently conducted a survey that sheds some light on substance use among workers in the food service industry, an industry that is often stereotyped for drug and alcohol use. Among some of the findings: 10% of workers report they work while under the influence...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Psychology Around the Net Adhd food service Forgetfulness Happiness Hormones Inattention osteocalcin Pollyanna hypothesis sexism Social Issues Stress Substance Use women Source Type: blogs
Publication date: Available online 13 September 2019Source: Computers in Human BehaviorAuthor(s): Michael Lyvers, Delilah Cutinho, Fred Arne ThorbergAbstractThe tendency to disclose personal information on Facebook has been examined in relation to the broad Big Five personality factors (extraversion, openness, neuroticism, conscientiousness, agreeableness), but the potential roles of more specific traits such as alexithymia and impulsivity are not known. The present study assessed the ability of these two traits, along with indices of disordered social media use, alcohol use, negative mood, and demographic factors, to pred...
Source: Computers in Human Behavior - Category: Information Technology Source Type: research
AbstractRecent studies have revealed that the gut microbiota participates in the psychiatric behavior changes in disorders associated with alcohol. But it still remains unknown whether alcoholism is involved in changes in gut microbiota and its underlying mechanism is also not clear. Here, we tested the gut microbiota of patients with alcoholism and conducted fecal microbiota transplantation (FMT) from patients with alcoholism to C57BL/6J mice whose gut microbiota had been sharply suppressed with antibiotics (ABX). Then we evaluated their alcohol preference degree, anxiety, and depression ‐like behaviors and social inter...
Source: BioFactors - Category: Biochemistry Authors: Tags: RESEARCH COMMUNICATION Source Type: research
This study was designed to examine the association between sleep problems and different categories of OAD amongst US adults. METHODS: We conducted an observational, cross-sectional study using a nationally representative sample of the US civilian non-institutionalized population from 2007 to 2008 National Health and Nutritional Examination Survey (NHANES). A total of 3204 study participants aged ≥35 years were stratified into four groups, using a self-reported history of asthma and data from spirometry: asthma-COPD overlap (ACO) (n = 70, 2.2%), asthma (n = 168, 5.2%), chronic obstru...
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
AbstractEvidence suggests that HIV-related stigma is a contributing factor to mental health and substance use problems among people living with HIV (PLWH). Limited research, however, has examined the differential effects that multiple stigma constructs, specifically, anticipated, enacted, and internalized stigma may have on mental health and alcohol use disorders among PLWH. Furthermore, no studies have examined this relationship within the larger context of urban life stressors. The purpose of this study was to examine associations of an overall HIV-related stigma measure and four HIV stigma subscales on depression, anxie...
Source: Journal of Urban Health - Category: Health Management Source Type: research
This study was designed to examine the association between sleep problems and different categories of OAD amongst US adults.MethodsWe conducted an observational, cross-sectional study using a nationally representative sample of the US civilian non-institutionalized population from 2007 to 2008 National Health and Nutritional Examination Survey (NHANES). A total of 3204 study participants aged ≥35 years were stratified into four groups, using a self-reported history of asthma and data from spirometry: asthma-COPD overlap (ACO) (n = 70, 2.2%), asthma (n = 168, 5.2%), chronic obstructive pu...
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
This study examined the prevalence of and sociodemographic characteristics associated with elevated symptoms of depression among clients seeking alcohol or other drug (AOD) treatment. Consenting clients attending two AOD outpatient clinics answered demographics, treatment questions and the Patient Health Questionnaire to assess depressive symptoms. Counts and percentages were calculated to determine the prevalence of elevated depressive symptoms. Logistic regression was used to model the odds of having elevated depressive symptoms for client demographics. Of the 203 clients who completed the survey (87% consent rate), 55% ...
Source: Community Mental Health Journal - Category: Psychiatry Authors: Tags: Community Ment Health J Source Type: research
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