PARP Inhibition Suppresses GR-MYCN-CDK5-RB1-E2F1 Signaling and Neuroendocrine Differentiation in Castration-Resistant Prostate Cancer.

CONCLUSION: The results of our study indicate an important role of GR-MYCN-CDK5R1/2-RB1-NED signaling in ENZ-induced, and PARP inhibitor-suppressed NEPC. We also demonstrated efficacy for OLA+DINA combination therapy in NEPC xenograft models.
PMID: 31439587 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - August 21, 2019 Category: Cancer & Oncology Authors: Liu B, Li L, Yang G, Geng C, Luo Y, Wu W, Manyam G, Korentzelos D, Park S, Tang Z, Wu C, Dong Z, Sigouros M, Sboner A, Beltran H, Chen Y, Corn P, Tetzlaff MT, Troncoso P, Broom BM, Thompson TC Tags: Clin Cancer Res Source Type: research