Frequency of Coronary Microvascular Dysfunction and Diffuse Myocardial Fibrosis (Measured by Cardiovascular Magnetic Resonance) in Patients with Heart Failure and Preserved Left Ventricular Ejection Fraction

Heart failure with preserved ejection fraction (HFpEF) is frequently accompanied by comorbidities and a systemic proinflammatory state, resulting in coronary microvascular dysfunction (CMD), as well as myocardial fibrosis. The purpose of this study is to examine the relationship between myocardial perfusion reserve (MPR) and diffuse myocardial fibrosis in patients with HFpEF using CMR. A single center study was performed in 19 patients with clinical HFpEF and 15 healthy control subjects who underwent quantitative first-pass perfusion imaging to calculate global MPR.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research