α-Ketoglutarate-Activated NF-κB Signaling Promotes Compensatory Glucose Uptake and Brain Tumor Development

Cancer cells often rewire their metabolic pathways for adaption to nutrient deficiency within tumors. Wang et  al. demonstrate here that GDH1 interacts with IKK complex and provides a local source of α-KG, which directly activates IKKβ and NF-κB signaling, thereby promoting glucose uptake, tumor cell survival, and brain tumor development.

Source: Molecular Cell - August 21, 2019 Category: Cytology Authors: Xiongjun Wang, Ruilong Liu, Xiujuan Qu, Hua Yu, Huiying Chu, Yajuan Zhang, Wencheng Zhu, Xueyuan Wu, Hong Gao, Bangbao Tao, Wenfeng Li, Ji Liang, Guohui Li, Weiwei Yang Tags: Article Source Type: research