Microparticles are related to cognitive and functional status from normal aging to dementia

Recently, we have shown that microparticles (MPs) levels derived from leukocytes (LMPs), endothelium (EMPs), neurons (NMPs) and those expressing tissue factor (TFMPs) were higher in Alzheimer's Disease (AD) patients when compared to cognitively healthy subjects. Therefore, in this study we proposed to investigate the correlation between MPs levels, cognitive performance and functional status in a sample of elderly individuals. We evaluated MPs derived from platelets (PMPs), LMPs, EMPs, NMPs and TFMPs in 43 participants, of whom 12 with probable dementia due to AD, 16 with mild cognitive impairment (MCI) and 15 with no objective cognitive or functional impairment.

Source: Journal of Neuroimmunology - August 20, 2019 Category: Allergy & Immunology Authors: A. Magalh ães Carolina, M. Campos Fernanda, M.G. Loures Cristina, G. Fraga Vanessa, C. de Souza Leonardo, C. Guimarães Henrique, T.G. Cintra Marco, A. Bicalho Maria, G. Carvalho Maria, P. Sousa Lirlândia, Caramelli Paulo, B. Gomes Karina Tags: Short Communication Source Type: research