Adult onset Henoch-Sch önlein purpura, treated with colchicine
Henoch-Sch önlein purpura (HSP) is an autoimmune complex, small vessel vasculitis characterized by nonthrombocytopenic palpable purpura, arthralgias, abdominal pain and nephritis. The etiology of HSP remains unclear. Incidence is highest in children, particularly 4 those 4 to 6 years in age. While adult onset HSP has been reported previously, it is diagnosed infrequently. Our case brings attention to the development of HSP while utilizing TNF-alpha inhibitors and the benefit of using colchicine as a treatment during an acute presentation of HSP.
CONCLUSION: Documenting carer, service provider and healthcare practitioner perspectives on skin infections provides a more informed understanding of the context in which treatment decisions are made. The ongoing need for culturally appropriate targeted, translational health education; improved treatment guidelines and feasible, painless treatments; and potential for the use of bush medicines for skin infections were themes that emerged. PMID: 31540550 [PubMed - in process]
No abstract available
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Discussion Pulmonary embolism (PE) is potentially life-threatening but fortunately rare event especially in the pediatric population. It was first described in children in 1861. PE is likely underreported because of minimal or non-specific clinical symptoms. The incidence is estimated at 0.05-4.2% with the 4.2% based on autopsy reports. It is probably also increasing as more central venous catheters (CVC) are used, and more children are surviving previously poor prognostic diseases. There is a bimodal distribution with cases
CONCLUSION: Elevated neutrophil count and NLR may be relevant markers for severe GI involvement and nephritis, whereas platelet count and MPV were the only laboratory parameters associated with disease recurrence. PMID: 31021301 [PubMed - as supplied by publisher]
ConclusionThe long-term morbidity of HSP is predominantly attributed to renal involvement. Patients with HSP, who have a high risk to develop nephritis, could be followed for longer periods of time. The Oxford classification is useful in predicting long-term outcomes of HSPN.
Abnormal urinalysis on day 7 in patients with IgA vasculitis (Henoch-Schönlein purpura). Nagoya J Med Sci. 2016 Dec;78(4):359-368 Authors: Kawashima N, Kawada JI, Nishikado Y, Kitase Y, Ito S, Muramatsu H, Sato Y, Kato T, Natsume J, Kojima S Abstract Rare progression to renal failure imposes a burden on children with IgA vasculitis (Henoch-Schönlein purpura, HSP). An abnormal urinalysis on day 7 (7d-UA) may be a surrogate marker for persistent nephritis, but this has not been established. We retrospectively analyzed the risk factors for persistent nephritis in a cohort of 138 children. Of 35 ...
We present a case of recurrent Henoch-Schonlein purpura (HSP) complicated by nephritis in an adult female initially categorized as IgA nephropathy (IgAN). We review the pathophysiologic basis of HSP nephritis as the variant of HSP accompanied by renal involvement and its pathogenetic commonality with IgA nephropathy. PMID: 27617937 [PubMed - as supplied by publisher]
This article is protected by copyright. All rights reserved. PMID: 27515240 [PubMed - as supplied by publisher]