Adult onset Henoch-Sch önlein purpura, treated with colchicine

Henoch-Sch önlein purpura (HSP) is an autoimmune complex, small vessel vasculitis characterized by nonthrombocytopenic palpable purpura, arthralgias, abdominal pain and nephritis. The etiology of HSP remains unclear. Incidence is highest in children, particularly 4 those 4 to 6 years in age. While adult onset HSP has been reported previously, it is diagnosed infrequently. Our case brings attention to the development of HSP while utilizing TNF-alpha inhibitors and the benefit of using colchicine as a treatment during an acute presentation of HSP.
Source: Journal of the American Academy of Dermatology - Category: Dermatology Source Type: research

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CONCLUSION: Documenting carer, service provider and healthcare practitioner perspectives on skin infections provides a more informed understanding of the context in which treatment decisions are made. The ongoing need for culturally appropriate targeted, translational health education; improved treatment guidelines and feasible, painless treatments; and potential for the use of bush medicines for skin infections were themes that emerged. PMID: 31540550 [PubMed - in process]
Source: Rural and Remote Health - Category: Rural Health Tags: Rural Remote Health Source Type: research
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Source: Lippincott's Bone and Joint Newsletter - Category: Orthopaedics Tags: Snapshot Source Type: news
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Source: AARP.org News - Category: American Health Source Type: news
Discussion Pulmonary embolism (PE) is potentially life-threatening but fortunately rare event especially in the pediatric population. It was first described in children in 1861. PE is likely underreported because of minimal or non-specific clinical symptoms. The incidence is estimated at 0.05-4.2% with the 4.2% based on autopsy reports. It is probably also increasing as more central venous catheters (CVC) are used, and more children are surviving previously poor prognostic diseases. There is a bimodal distribution with cases
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Source: Journal of Pain Research - Category: Anesthesiology Tags: Journal of Pain Research Source Type: research
CONCLUSION: Elevated neutrophil count and NLR may be relevant markers for severe GI involvement and nephritis, whereas platelet count and MPV were the only laboratory parameters associated with disease recurrence. PMID: 31021301 [PubMed - as supplied by publisher]
Source: Postgraduate Medicine - Category: Internal Medicine Tags: Postgrad Med Source Type: research
ConclusionThe long-term morbidity of HSP is predominantly attributed to renal involvement. Patients with HSP, who have a high risk to develop nephritis, could be followed for longer periods of time. The Oxford classification is useful in predicting long-term outcomes of HSPN.
Source: Clinical and Experimental Nephrology - Category: Urology & Nephrology Source Type: research
Abnormal urinalysis on day 7 in patients with IgA vasculitis (Henoch-Schönlein purpura). Nagoya J Med Sci. 2016 Dec;78(4):359-368 Authors: Kawashima N, Kawada JI, Nishikado Y, Kitase Y, Ito S, Muramatsu H, Sato Y, Kato T, Natsume J, Kojima S Abstract Rare progression to renal failure imposes a burden on children with IgA vasculitis (Henoch-Schönlein purpura, HSP). An abnormal urinalysis on day 7 (7d-UA) may be a surrogate marker for persistent nephritis, but this has not been established. We retrospectively analyzed the risk factors for persistent nephritis in a cohort of 138 children. Of 35 ...
Source: Nagoya Journal of Medical Science - Category: Global & Universal Tags: Nagoya J Med Sci Source Type: research
We present a case of recurrent Henoch-Schonlein purpura (HSP) complicated by nephritis in an adult female initially categorized as IgA nephropathy (IgAN). We review the pathophysiologic basis of HSP nephritis as the variant of HSP accompanied by renal involvement and its pathogenetic commonality with IgA nephropathy. PMID: 27617937 [PubMed - as supplied by publisher]
Source: Dermatol Online J - Category: Dermatology Authors: Tags: Dermatol Online J Source Type: research
This article is protected by copyright. All rights reserved. PMID: 27515240 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - Category: Dermatology Authors: Tags: Br J Dermatol Source Type: research
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