Small molecule grp94 inhibitors with antiviral activity against Dengue and Zika virus.

This study defines grp94 as a crucial host factor for flavivirus replication and identified CDDO-me as a potent small molecule inhibitor of flavivirus infection. Inhibition of grp94 may contribute to the antiviral activity of CDDO-me. Further investigation of grp94 inhibitors may lead to a new class of broad-spectrum anti-flaviviral medications. PMID: 31421166 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/31421166?dopt=Abstract

Source: Antiviral Research - August 13, 2019 Category: Virology Authors: Rothan HA, Zhong Y, Sanborn MA, Teoh TC, Ruan J, Yusof R, Hang J, Henderson MJ, Fang S Tags: Antiviral Res Source Type: research