Researcher at Arkansas Children's, UAMS Gets $3.1M Grant for Study

A researcher at Arkansas Children’s Research Institute and the University of Arkansas for Medical Sciences has received a $3.1 million National Institutes of Health grant to study how maternal obesity during pregnancy influences infant brain development.
Source: Arkansas Business - Health Care - Category: American Health Source Type: news

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ConclusionTo our knowledge, this study provides the first population ‐based pharmacokinetic model in obese patients with sepsis or septic shock. The nomograms generated from this pharmacokinetic model provides a simplified approach to vancomycin dosing in this patient population.
Source: Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy - Category: Drugs & Pharmacology Authors: Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Authors: Sucker C Abstract Venous thromboembolisms and pulmonary embolisms are one of the main causes of morbidity and mortality in pregnancy. The increased risk of thrombotic events caused by the physiological changes during pregnancy alone does not justify any medical antithrombotic prophylaxis. However, if there are also other risk factors such as a history of thromboses, hormonal stimulation as part of fertility treatment, thrombophilia, increased age of the pregnant woman, severe obesity or predisposing concomitant illnesses, the risk of thrombosis should be re-evaluated - if possible by a coagulation speciali...
Source: Geburtshilfe und Frauenheilkunde - Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research
Indigenous populations worldwide have a high prevalence of type 2 diabetes mellitus (T2D),[1] and early age of onset.[2] The causes of increased rates of T2D are likely multiple and complex. However, social determinants of health appear to be associated with differences in prevalence across populations, including in youth.[3] The prevalence of T2D is directly related to the prevalence of obesity which is also influenced by social determinants of health. Understanding the relationship between social determinants of health and neonatal adiposity may inform early life interventions to improve metabolic health.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
Abstract Animal studies indicated that bisphenol A (BPA) exposure during pregnancy may disrupt thyroid function which is critical for fetal development. However, few epidemiological studies have examined this topic and the results were inconsistent. We aimed to evaluate whether prenatal BPA exposure is associated with thyroid hormone levels in Chinese mothers and newborns with stratification by maternal body mass index (BMI). BPA concentration were measured in urine samples collected from 555 women at late pregnancy. Maternal serum free thyroxin (FT4), thyroid-stimulating hormone (TSH) and thyroid peroxidase antib...
Source: Environmental Science and Pollution Research International - Category: Environmental Health Authors: Tags: Environ Sci Pollut Res Int Source Type: research
ConclusionsCohort studies in the GCC have predominantly focused on reproductive and medical exposures. Obese pregnant women are at an increased risk of undergoing CS delivery or macrosomic births. Longer-term studies that explore a wider range of environmental and biological exposures and outcomes relevant to the GCC region are needed.Systematic review registrationPROSPERO CRD42017068910
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
ConclusionAn attempt of vaginal birth is a reasonable option for short stature women. Maternal height could be included in the selection criteria for planned birth center or home birth.The customized gestational-related optimal weigh could be useful to identify large of gestational age fetus.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Conclusions: StEP led to reduced obesity-promoting feeding practices and styles, and increased knowledge and provides great potential for population-scalability. PMID: 31934788 [PubMed - as supplied by publisher]
Source: Childhood Obesity - Category: Eating Disorders & Weight Management Tags: Child Obes Source Type: research
Authors: Azzaroli F, Mazzella G, Marchesini G, Brodosi L, Petroni ML Abstract INTRODUCTION: Fatty liver is rather common in pregnancy, occurring in two totally different conditions, i.e, nonalcoholic fatty liver disease (NAFLD) in pregnancy and acute fatty liver of pregnancy (AFLP). The former is a common condition, resulting by chance association because of the epidemics of obesity and the older age of many pregnant women in Western countries; the latter is a rare disease whose pathophysiology is still incompletely understood.Areas covered:We reviewed the evidence-based knowledge on fatty liver in/of pregnancy. Fo...
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
This study aimed to compare health ‐promoting, dietary patterns and social support in normal and overweight pregnant women.DesignAn unmatched case –control design was used.MethodsA total of 360 pregnant women were selected using multistage cluster sampling and divided into two groups of normal and overweight cases. Data were collected using demographic and obstetrics characteristics, health ‐promoting lifestyle, perceived social support and eating behaviour questionnaires.ResultsThe evaluation of the health ‐promoting behaviours and dietary patterns demonstrated a significant difference between the mean of tota...
Source: Nursing Open - Category: Nursing Authors: Tags: RESEARCH ARTICLE Source Type: research
This study was conducted with the aim to assess obesity-related adverse maternal, neonatal and perinatal outcomes using new Asian Indian guidelines.MethodologyPregnant women up to 16-week gestation on first visit were enrolled. There were two exposure groups: one with BMI  
Source: The Journal of Obstetrics and Gynecology of India - Category: OBGYN Source Type: research
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