Changes in gonadal function at different stages of chronic restraint stress-induced depression animals

Publication date: Available online 17 August 2019Source: Physiology &BehaviorAuthor(s): Biyuan Liu, Li Zhao, Chen Yue, Meng Qian, Ming XieAbstractThe aim of this study was to determine the time-dependent changes in adolescent male gonadal function due to chronic restraint stress (CRS)-induced depression in a rat model and to elucidate the underlying mechanism. CRS was established in adolescence male Wistar rats by placing the animals in a cylinder for 3 h every day for 28 days, during which time the general behavior and serum hormonal levels were routinely monitored. The CRS model rats showed anxiety-like behavior in the open field test (OFT) and sucrose consumption test, and their body weights also decreased significantly on the 14th, 21st and 28th days. The CRS rats showed a significant decrease in serum 5-hydroxytryptamine (5-HT) after 14 days of restraint and an increase in the CORT and NE levels after 21 days of restraint, while the serum GnRH levels increased significantly on the 14th and 21st days and decreased significantly over the last 7 days. In contrast, the FSH and LH levels decreased significantly from the 14th day to the 28th day, while the PRL and E2 levels were significantly higher during the same time period compared to those of the controls. The serum T levels also decreased significantly in the CRS group on the 21st and the 28th days, with the lowest levels occurring on day 28. Histopathological examination showed that testicular damage was a...
Source: Physiology and Behavior - Category: Physiology Source Type: research

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Conclusion/Importance: This study indicates that future research should take into account substance use patterns in adults engaging in NSI behaviors. PMID: 31519128 [PubMed - as supplied by publisher]
Source: Substance Use and Misuse - Category: Addiction Tags: Subst Use Misuse Source Type: research
ConclusionsOur findings suggest a dose-effect mechanism modulating the relationship between treatment-related SI and AS. AS symptoms may need to be monitored closely in the weeks that follow the introduction of an antidepressant treatment.
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Conclusion: Gabapentin as an adjunctive drug could be more effective in reducing the severity of GI symptoms in patients with dyspepsia, especially neurological symptoms (such as pain, reflux, and indigestion). PMID: 31516891 [PubMed]
Source: Biomed Res - Category: Research Authors: Tags: Adv Biomed Res Source Type: research
Previously observed antidepressant-like effects of caffeine in adolescent rats have been shown in individually housed (IH) rats. Because IH presents a social stressor that may create depressant-like effects in control animals, this study sought to compare the effects of chronic caffeine in IH and pair-housed (PH) adolescent male and female rats. Housing conditions began on postnatal day 24 (P24) and half of the rats were provided caffeine (0.25 g/l) in their drinking water beginning on P28. Open-field behavior was assessed on P42, a light/dark test was conducted on P43, and a forced swim test was conducted on P44–P45...
Source: Behavioural Pharmacology - Category: Drugs & Pharmacology Tags: Research Reports Source Type: research
US suicide rates have risen by 41 percent in just three years. → Support PsyBlog for just $4 per month. Enables access to articles marked (M) and removes ads. → Explore PsyBlog's ebooks, all written by Dr Jeremy Dean: Accept Yourself: How to feel a profound sense of warmth and self-compassion The Anxiety Plan: 42 Strategies For Worry, Phobias, OCD and Panic Spark: 17 Steps That Will Boost Your Motivation For Anything Activate: How To Find Joy Again By Changing What You Do
Source: PsyBlog | Psychology Blog - Category: Psychiatry & Psychology Authors: Tags: Suicide subscribers-only Source Type: blogs
DISCUSSIONWhereas some AD biomarkers showed to be associated with affective symptoms in AD, most evidence was inconsistent. This is likely due to differences in study design or heterogeneity in affective symptoms. Directions for future research are given.
Source: Neuroscience and Biobehavioral Reviews - Category: Neuroscience Source Type: research
Publication date: October 2019Source: Epilepsy &Behavior, Volume 99Author(s): Zilin Wang, Zhiwen Luo, Shunhua Li, Zhiwen Luo, Zilin WangAbstractObjectiveAnxiety is a common neurological condition often comorbid with epilepsy, with approximately 20% of patients with epilepsy exhibiting symptoms of anxiety. Despite this prevalence, accurate and efficacious tools designed to screen for anxiety specifically in patients with epilepsy have not yet been developed. The purpose of this study is to systematically review the literature and better understand this relationship.MethodsOvid MEDLINE, EMBASE, and PsyclNFO were searched...
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: Available online 13 September 2019Source: Computers in Human BehaviorAuthor(s): Michael Lyvers, Delilah Cutinho, Fred Arne ThorbergAbstractThe tendency to disclose personal information on Facebook has been examined in relation to the broad Big Five personality factors (extraversion, openness, neuroticism, conscientiousness, agreeableness), but the potential roles of more specific traits such as alexithymia and impulsivity are not known. The present study assessed the ability of these two traits, along with indices of disordered social media use, alcohol use, negative mood, and demographic factors, to pred...
Source: Computers in Human Behavior - Category: Information Technology Source Type: research
ConclusionsThe PIP intervention seems not to be effective reducing burden, but appears to have a positive result on general mental health. The program was well received and valued by caregivers.
Source: Research in Developmental Disabilities - Category: Disability Source Type: research
In conclusion, our novel findings further validate the use of zebrafish as a suitable tool for modeling epilepsy-related comorbidities in translational neuropsychiatric research.Graphical abstract
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
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