A Polygenic Score for Body Mass Index is Associated with Depressive Symptoms via Early Life Stress: Evidence for Gene-Environment Correlation

Publication date: Available online 16 August 2019Source: Journal of Psychiatric ResearchAuthor(s): Reut Avinun, Ahmad R. HaririAbstractIncreasing childhood obesity rates are associated with not only adverse physical, but also mental health outcomes, including depression. These negative outcomes may be caused and/or exacerbated by the bullying and shaming overweight individuals experience. As body mass index (BMI) can be highly heritable, we hypothesized that a genetic risk for higher BMI, will predict higher early life stress (ELS), which in turn will predict higher depressive symptoms in adulthood. Such a process will reflect an evocative gene-environment correlation (rGE) wherein an individual's genetically influenced phenotype evokes a reaction from the environment that subsequently shapes the individual’s health. We modeled genetic risk using a polygenic score of BMI derived from a recent large GWAS meta-analysis. Self-reports were used for the assessment of ELS and depressive symptoms in adulthood. The discovery sample consisted of 524 non-Hispanic Caucasian university students from the Duke Neurogenetics Study (DNS; 278 women, mean age 19.78±1.23 years) and the independent replication sample consisted of 5,930 white British individuals from the UK biobank (UKB; 3,128 women, mean age 62.66±7.38 years). A significant mediation effect was found in the DNS (indirect effect=.207, bootstrapped SE=.10, bootstrapped 95% CI: .014 to .421), and then replicated...
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research

Related Links:

CONCLUSIONS In patients ≥60 years in a primary healthcare setting, multimorbidity predictors of pre-frailty and frailty included a decline in cognitive function and renal function. PMID: 31507272 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
ConclusionsWe conclude the review by emphasizing missing knowledge gaps that remain and future research opportunities needed to implement FKBP51 as a drug target for stress-related obesity or T2D.
Source: Molecular Metabolism - Category: Endocrinology Source Type: research
CONCLUSIONS: Our findings suggest that lower levels of housing affordability contribute to worse risk profiles for cardiovascular disease. Policies that make housing more affordable may help reduce the population burden of cardiovascular disease. PMID: 31518890 [PubMed - as supplied by publisher]
Source: Health and Place - Category: Environmental Health Authors: Tags: Health Place Source Type: research
This study used data from the Fragile Families Child Wellbeing Study (FFCWS) to investigate the research questions. FFCWS is a national dataset that has information on 4898 women, and their children, from predominantly nonmarital, low-income minority groups in the United States. This study used information collected at the birth of the child (wave 1) through age 9 years (wave 5). The analytic sample consisted of 3500 mother-children dyads. Group-based trajectory modeling and multivariable logistic regression were used. Results: The results indicated that there was no association between maternal depression and childhood ob...
Source: Childhood Obesity - Category: Eating Disorders & Weight Management Tags: Child Obes Source Type: research
Background: Childhood overweight and obesity have become a primary social and public health concern. Over the past 30 years, rates of childhood overweight and obesity in the United States have i...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
Abstract Pulmonary arterial hypertension (PAH) is a fatal disease with a median survival of only 5-7 years. PAH is characterized by remodeling of the pulmonary vasculature causing reduced pulmonary arterial compliance (PAC) and increased pulmonary vascular resistance (PVR), ultimately resulting in right ventricular failure and death. Better therapies for PAH will require a paradigm shift in our understanding of the early pathophysiology. PAC decreases before there is an increase in the PVR. Unfortunately, current treatment has little effect on PAC. The loss of compliance correlates with extracellular matrix remode...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research
We describe the prevalence, hazard ratios (HRs), and population-attributable fractions (PAFs) for cardiovascular disease and mortality associated with a cluster of behavioural factors (ie, tobacco use, alcohol, diet, physical activity, and sodium intake), metabolic factors (ie, lipids, blood pressure, diabetes, obesity), socioeconomic and psychosocial factors (ie, education, symptoms of depression), grip strength, and household and ambient pollution. Associations between risk factors and the outcomes were established using multivariable Cox frailty models and using PAFs for the entire cohort, and also by countries grouped ...
Source: The Lancet - Category: General Medicine Source Type: research
September is   Polycystic Ovary Syndrome Awareness Month and is an excellent time to focus on the latest Cochrane evidence.Polycystic ovary syndrome (PCOS) is a very common condition affecting 8% to 13% of women. Being overweight worsens all clinical features of PCOS. These clinical features include reproductive issues such as reduced frequency of ovulation and irregular menstrual cycles, reduced fertility, polycystic ovaries onultrasound and high levels of male hormones such as testosterone, which can cause unwanted facial or body hair growth and acne. PCOS is also associated with metabolic features, withrisk factors...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
ConclusionsAdults with atopic eczema are more likely to develop new depression and anxiety. For depression, we observed a dose-response relationship with atopic eczema severity.
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
AbstractPurposeIncidence and mortality rates of uterine cancer are increasing and, obesity, which is also rising, has been associated with uterine cancer development and mortality. A recent study found that poor sleep quality is common among endometrial cancer survivors and those with obesity had more sleep disturbances than those having normal weight. However, it is unclear if higher levels of obesity (Class III, BMI ≥ 40 kg/m2), which are rising rapidly, are differentially associated with sleep as well as depression and quality of life in endometrial cancer survivors.MethodsWe evaluated sleep, depression, ...
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
More News: Brain | Depression | Eating Disorders & Weight Management | Environmental Health | Genetics | Men | Neurology | Obesity | Psychiatry | Students | Study | UK Health | Universities & Medical Training | Women