Effect of Dipeptidyl Peptidase 4 Inhibition on Arterial Blood Pressure is Context Dependent [Dipeptidyl Peptidase Inhibition]

In conclusion: (1) The effects of DPP4 inhibitors on blood pressure are context dependent; (2) The context-dependent effects of DPP4 inhibitors are due in part to differential renovascular responses to its most important substrates (NPY1–36 and GLP-1(7–36)NH2); (3) Y1 receptor antagonists may prevent the prohypertensive and possibly augment the antihypertensive effects of DPP4 inhibitors.

Source: Hypertension - December 10, 2014 Category: Cardiology Authors: Jackson, E. K., Mi, Z., Tofovic, S. P., Gillespie, D. G. Tags: Animal models of human disease, Other hypertension, Other Vascular biology Dipeptidyl Peptidase Inhibition Source Type: research