Partial thickness rotator cuff tears: Patient demographics and surgical trends within a large insurance database
ConclusionReported cases of PTRCT and its surgical repair have both increased substantially over time. Approximately 11.70% of patients with PTRCT undergo either open or arthroscopic procedure as a means of surgical repair. With the growing popularity of arthroscopic procedures for rotator cuff repair, further investigation should be performed to analyze trends and risk factors for PTRCT, a seemingly underrepresented orthopedic condition.
Abstract: The US industrial revolution led to a significant increase in the amount of dietary sugar consumed annually. The impact has become a public health crisis over the past several decades. The consequences are seen in the dramatic rise in rates of obesity, type 2 diabetes mellitus, and cardiovascular disease.
The drug, Rybelsus (semaglutide) is the first pill in a class of drugs called glucagon-like peptide (GLP-1) approved for use in the United States. Before Rybelsus, the drug had to be injected.
The panel also recommends approval of Qtrilmet, a fixed-dose combination of metformin hydrochloride/saxagliptin/dapagliflozin for treatment of type 2 diabetes.International Approvals
Publication date: Available online 18 September 2019Source: Journal of the Formosan Medical AssociationAuthor(s): Ting-Chen Chang, Sheng-Mou Hsiao, Pei-Chi Wu, Chi-Hau Chen, Wen-Yih Wu, Ho-Hsiung LinBackground/PurposeThe most suitable surgical technique for pelvic organ prolapse (POP) remains undetermined. The aim of this study was to compare clinical outcomes of the tailored transvaginal mesh (TVM) surgery and vaginal native tissue repair (NTR) surgery for POP.MethodsBetween November 2011 and August 2014, medical records of 339 women receiving POP surgeries were reviewed.ResultsCompared with the NTR group (n = 1...
We describe the first case of 2 consecutive acute septic arthritis infections of both knees caused by the same virulent strain of Kingella kingae belonging to the virulent sequence type complex 14, in a 16-month-old boy. Both infections occurred after viral upper respiratory tract infections.
Authors: Dhont S, de Niel C, van Mieghem C PMID: 31536466 [PubMed - as supplied by publisher]
Publication date: October 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 7Author(s): Elizabeth Sellers
Publication date: October 2019Source: Canadian Journal of Diabetes, Volume 43, Issue 7Author(s):
In this study, we found that cofilin competes with tau for direct microtubule binding in vitro, in cells, and in vivo, which inhibits tau-induced microtubule assembly. Genetic reduction of cofilin mitigates tauopathy and synaptic defects in Tau-P301S mice and movement deficits in tau transgenic C. elegans. The pathogenic effects of cofilin are selectively mediated by activated cofilin, as active but not inactive cofilin selectively interacts with tubulin, destabilizes microtubules, and promotes tauopathy. These results therefore indicate that activated cofilin plays an essential intermediary role in neurotoxic signaling th...
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