Study Looks at Metformin and Atypical Antipsychotics

It's well known that atypical antipsychotics (AAPs) such as Zyprexa and Seroquel cause weight gain. The prescribing information for all AAPs contains warnings that blood sugar should be monitored because this weight gain can be associated with diabetes, particularly in people with existing risk factors. I had those risk factors - diabetes is prevalent in my family history. From various psychiatric medications, including Seroquel, I gained a total of 80 pounds (to 205 pounds) and weighed 190 when I became concerned about my blood sugar and contacted my doctor. Sure enough, I had developed diabetes. The doctor started me on a medication called Metformin (glucophage). Within two months I dropped 10 pounds (though have now hit a plateau at 180, still 35-45 pounds over my goal weight). A study was published in the Journal of Clinical Psychiatry looking at the effect of Metformin on weight, body measurements and insulin resistance in patients taking AAPs. Researchers reviewed 6 existing studies. They found that while there was no significant reduction in the risk of diabetes, Metformin significantly reduced weight, body mass index (BMI), waist circumference and insulin resistance compared to placebo. They concluded that while more studies are needed, the "available data support consideration of this intervention in clinical practice." Does this mean everyone who has gained weight from taking one of the atypical antipsychotics should be put on Metformin? No, of course not. It do...
Source: About.com Bipolar Disorder - Category: Psychiatry Source Type: news