Sewage Study Reveals Half Of Tamiflu Prescriptions Went Unused During 2009 H1N1 Swine Flu Pandemic

A new study concludes that approximately half of the prescriptions of Tamiflu during the 2009-10 influenza pandemic went unused in England. The unused medication represents approximately 600,000 courses of Tamiflu at a cost of around 7.8 million pounds to the UK taxpayer. The novel scientific method used in the study could help measure and improve the effectiveness of future pandemic flu strategies...
Source: Health News from Medical News Today - Category: Consumer Health News Tags: Flu / Cold / SARS Source Type: news

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Vaccines are among the most effective public health tools for combating certain infectious diseases such as influenza. The role of the humoral immune system in vaccine-induced protection is widely appreciated; however, our understanding of how antibody specificities relate to B cell function remains limited due to the complexity of polyclonal antibody responses. To address this, we developed the Spec-seq framework, which allows for simultaneous monoclonal antibody (mAb) characterization and transcriptional profiling from the same single cell. Here, we present the first application of the Spec-seq framework, which we applie...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Condition:   Influenza, Avian Interventions:   Biological: GHB04L1;   Other: Placebo Sponsor:   AVIR Green Hills Biotechnology AG Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This report highlights the potential of variant influenza outbreaks associated with agricultural fair settings in the United States, especially after direct or indirect swine contact.Morbidity &Mortality Weekly Report
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news
We present a rapid Raman assay for on-site analysis of stockpiled drugs in aqueous solution. This approach was tested on Tamiflu (oseltamivir phosphate). Tamiflu is a drug approved by the FDA for treatment of influenza and is the most common antiviral included in stockpiles for use in the event of a national emergency. Rapid assays were performed on three concentrations (30, 45, and 75 mg) of oseltamivir using three different portable &handheld Raman instruments. PLS regression models were developed to establish a calibration curve and applied to the Tamiflu samples. Raman assay values were compared against the stand...
Source: Analytica Chimica Acta - Category: Chemistry Authors: Tags: Anal Chim Acta Source Type: research
CONCLUSION: To improve the early prescription of oseltamivir during the influenza season, two recommendations are essential: oseltamivir availability in the emergency department pharmacy, awareness of physicians of the need to prescribe to any patient hospitalized for a lower respiratory tract infection treatment with a neuraminidase inhibitor upon admission to the emergency department. PMID: 30446349 [PubMed - as supplied by publisher]
Source: Medecine et Maladies Infectieuses - Category: Infectious Diseases Tags: Med Mal Infect Source Type: research
Discussion Guillian-Barré syndrome (GBS) is an acquired, acute, inflammatory, demyelinating polyneuropathy. It is the most common cause of acute and subacute flaccid paralysis in children. GBS causes about 0.4-1.3 cases per 100,000 persons/year in children. It can occur in any age group and the incidence increases among all age groups until a peak in the 50s. Both genders are affected and there may be a slight increase in males. GBS usually occurs 2-4 weeks after a prodromal gastroenteritis or respiratory illness. GBS causes autoantibody production against Schwann cells of the neuron and the axon itself. There is ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
In this study, we aimed to identify mutations related to mammalian adaptation of H9N2 influenza virus. We found that mouse-adapted viruses had several mutations in hemagglutinin (HA), PB2, PA, and PB1. Among the detected mutations, PB1-K577E was a novel mutation that had not been previously reported to involve mammalian adaptation. A recombinant H9N2 virus bearing only the PB1-K577E mutation showed enhanced pathogenicity in mice, with increased virus titers in nasal turbinates compared to that in mice infected with the wild-type virus. In addition, the PB1-K577E mutation increased virus polymerase activity in human cell cu...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
The TWiVidae review universal influenza vaccines that are in clinical trials, and discovery of an atypical parvovirus that causes chronic kidney disease in middle aged, immunocompromised laboratory mice.  Click arrow to play Download TWiV 520 (70 MB .mp3, 116 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show […]
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology chronic kidney disease clinical trial HA stalk vaccine immunocompromised immunosufficient influenza kidney fibrosis parvovirus peptide tubulointerstitial nephropathy universal influenza vaccine viral viruses Source Type: blogs
INTRODUCTION According to the Center for Research on the Epidemiology of Disasters (CRED), natural disasters are classified as geophysical, metrological, hydrological, climatological and biological. These five disaster types encompass 12 disaster types and more than 30 sub-types. The 20th Century witnessed an increase in disaster losses, and this has continued its upward trend in the current Century. Climate change will increase the rate of increase of disasters, particularly those of meteorological origin. This is reflected in the fact that, of all natural hazards, floods are the most frequent and their impacts are also i...
Source: PLOS Currents Disasters - Category: Global & Universal Authors: Source Type: research
In the past decade, the H1N1 virus and Ebola are just two of the diseases whose spread was spurred by international airline travel. Screening passengers at airports, therefore, could be one key method for slowing the global spread of infectious diseases. And although a team lead by UCLA researchers has found that airport screening misses at least half of infected travelers, the scientists say that rate could be improved. Their research was published in eLife, a highly regarded open-access online science journal. The life scientists used a mathematical model to analyze screening for six viruses: the SARS coronavirus, the Eb...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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