Investigating the effects of additional truncating variants in DNA-repair genes on breast cancer risk in BRCA1-positive women

Inherited pathogenic variants in BRCA1 and BRCA2 are the most common causes of hereditary breast and ovarian cancer (HBOC). The risk of developing breast cancer by age 80 in women carrying a BRCA1 pathogenic vari...

Source: BMC Cancer - August 8, 2019 Category: Cancer & Oncology Authors: Ilnaz Sepahi, Ulrike Faust, Marc Sturm, Kristin Bosse, Martin Kehrer, Tilman Heinrich, Kathrin Grundman-Hauser, Peter Bauer, Stephan Ossowski, Hana Susak, Raymonda Varon, Evelin Schr öck, Dieter Niederacher, Bernd Auber, Christian Sutter, Norbert Arnold Tags: Research article Source Type: research