The Effect Of Middle-Dose Statin Therapy On The Vascular Endothelium Function In Patients With A Combined Course Of Hypertension, Type 2 Diabetes And Subclinical Hypothyroidism

Background and Aims: To study the influence of middle-dose statin therapy on endothelial function in the combined course of arterial hypertension (AH), type 2 diabetes mellitus (DM2T) and subclinical hypothyroidism (SH).
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Posters 26 - 29 May, 2019 Source Type: research

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It's no secret that there's a multitude of unhappy nurses out there in the world. From mandatory overtime to unhealthy nurse-patient ratios, I admit there are very valid reasons for this seeming epidemic of discontent. So, is the nursing glass half-full or half-empty? I guess it depends on who you're drinking with (and perhaps what you're drinking). Photo by Jana Sabeth on UnsplashReasons To Be Cheerful---Or NotThis blog post isn't really about the aforementioned multitude of reasons that explain nurses'rampant unhappiness. A new study mentioned recently on Twitter states that a full one-third of nurses...
Source: Digital Doorway - Category: Nursing Tags: nurse nurse identity nurses nursing nursing careers nursing identity Source Type: blogs
Hepcidin protects pulmonary artery hypertension in rats by activating NF-κB/TNF-α pathway. Eur Rev Med Pharmacol Sci. 2019 Sep;23(17):7573-7581 Authors: Liu WY, Wang L, Lai YF Abstract OBJECTIVE: The pulmonary artery hypertension (PAH) model was established in rats in this study. Therefore, we aimed to elucidate the protective role of Hepcidin in PAH rats and its underlying mechanism. MATERIALS AND METHODS: 24 male Sprague Dawley (SD) rats were randomly divided into sham group, PAH group and Hepcidin group, with 8 rats in each group. After animal procedures, hemodynamic parameters and r...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: Our study firstly established that the G allele and C/G genotype of rs184187143 single nucleotide polymorphism (SNP) in SLC26A6 gene was closely linked with the increased risk for the development of the diabetic ketoacidosis of GDM. PMID: 31539142 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
CONCLUSIONS: TUG1 is downregulated in DN. The overexpression of TUG1 could suppress the proliferation and ECM accumulation of mesangial cells via inhibiting the PI3K/AKT pathway. PMID: 31539141 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
We report a case of septic shock caused by this pathogen. A 78-year-old man affected by diabetes and hypertension was admitted for fever in our Emergency Department. He reported fever (37.7°C) with normal values of blood pressure, heart rate and saturation of oxygen. Laboratory studies showed increased values of procalcitonin and normal white-cell level. Blood cultures were collected and an empirical antibiotic therapy was started. He reported six days earlier a bite of a dog at the right hand. During the following days the patient presented a deterioration of clinical conditions with fever, asthenia and comparison of ...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Spontaneous Model of Sjögren's Syndrome in NOD Mice. Curr Protoc Pharmacol. 2019 Sep;86(1):e65 Authors: Scuron MD, Fay B, Oliver J, Smith P Abstract The non-obese diabetic (NOD) mouse model is the most widely described and validated method for investigating human primary Sjögren's syndrome (SS) and represents a useful model for translational studies. However, the systemic disease manifestation in NOD mice is sensitive to the housing environment, as stress modulates the immune system, so it is essential to confirm that readouts are robust, reproducible, and sensitive to known clinical treatmen...
Source: Current Protocols in Pharmacology - Category: Drugs & Pharmacology Tags: Curr Protoc Pharmacol Source Type: research
ConclusionsGöttingen Minipigs fed CDAHFD developed pronounced steatosis with inflammation around steatotic hepatocytes and incipient fibrosis, thereby showing potential as a model for human NASH. Further studies are needed to investigate the period needed for marked fibrosis to develop.
Source: Journal of Clinical and Experimental Hepatology - Category: Gastroenterology Source Type: research
This study is a post-hoc analysis of steroid hormones before and after administration of pharmacological doses of soy isoflavones in a large cohort of men and women from two independent studies. Isoflavones are reported to inhibit mineralo- and glucocorticoid hormone production as well as reproductive steroids in vivo and in vitro. We focused on cytochrome P450 17α-hydroxylase (CYP17A1) which catalyses the production of dehydroepiandrosterone (DHEA), in the androgen biosynthesis pathway to elucidate effects on sex steroids in vitro. Design and Setting: Effects of soy isoflavones on steroid levels in two studies comp...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 16 March 2017 Source:Journal of Ayurveda and Integrative Medicine Author(s): Swathi Gowda, Sriloy Mohanty, Apar Saoji, Raghuram Nagarathna A 50-year-old male participant with sedentary lifestyle, diagnosed with Metabolic Syndrome (MetS) [obesity, Type-2 diabetes mellitus, hypertension] and hypothyroidism since 2013, was administered integrated Yoga and Naturopathy (IYN) for 6 weeks as a tailor made individualized protocol at the residential integrative medical facility in Bangalore between October and November 2015. The results showed reduction in weight (97.9 kg to 74.6 kg), B...
Source: Journal of Ayurveda and Integrative Medicine - Category: Complementary Medicine Source Type: research
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 74-year-old woman is evaluated in the emergency department for several hours of altered mental status. She is from out-of-state and is visiting with relatives. One of her young relatives was recently ill with gastrointestinal symptoms. The patient developed anorexia 3 days ago and vomiting 2 days ago. She has been unable to tolerate any liquid or solid foods for the last 24 hours. Medical history is significant for type 2 diabetes mellitus, hypertension, hyperlipidemia, and hypothyroidism. Medications ...
Source: Kevin, M.D. - Medical Weblog - Category: Journals (General) Authors: Tags: Conditions Diabetes Source Type: blogs
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