Reward, control & decision-making in cannabis use disorder: insights from functional MRI.

Reward, control & decision-making in cannabis use disorder: insights from functional MRI. Br J Radiol. 2019 Jul 31;:20190165 Authors: Fatima H, Howlett AC, Whitlow CT Abstract The recreational consumption of cannabis has increased significantly across the world with an estimated 180 million people currently using. In the United States, 4.1 million are currently diagnosed with cannabis use disorder. Cannabis dependence and abuse was combined into a single entity as a behavioral disorder with a problematic pattern of cannabis use and termed cannabis use disorder by the Diagnostic and Statistical Manual of Mental Disorders. Chronic use of cannabis has been linked with region-specific effects across the brain mediating reward processing, cognitive control and decision-making that are central to understanding addictive behaviors. This review presents a snapshot of the current literature assessing the effects of chronic cannabis use on human brain function via functional MRI. Studies employing various paradigms and contrasting cognitive activation amongst cannabis users and non-users were incorporated. The effects of Δ9-THC in marijuana and other preparations of cannabis are mediated by the endocannabinoid system, which is also briefly introduced. PMID: 31364398 [PubMed - as supplied by publisher]
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research