Evaluation of 11C-LSN3172176 as a Novel PET Tracer for Imaging M1 Muscarinic Acetylcholine Receptors in Nonhuman Primates

Conclusion: 11C-LSN3172176 exhibits excellent in vivo binding and imaging characteristics in nonhuman primates and appears to be the first appropriate radiotracer for PET imaging of human M1 AChR.

Source: Journal of Nuclear Medicine - July 31, 2019 Category: Nuclear Medicine Authors: Nabulsi, N. B., Holden, D., Zheng, M.-Q., Bois, F., Lin, S.-F., Najafzadeh, S., Gao, H., Ropchan, J., Lara-Jaime, T., Labaree, D., Shirali, A., Slieker, L., Jesudason, C., Barth, V., Navarro, A., Kant, N., Carson, R. E., Huang, Y. Tags: Translational Source Type: research