Fatal doxepin intoxication – Suicide or slow gradual intoxication?
Abstract: The differentiation of intoxication courses is one of the most difficult challenges for forensic pathologists and toxicologists. The case of a 52-year-old female inpatient of a psychiatric clinic with multiple medications who died from doxepin intoxication is reported. Concentrations of doxepin metabolites and isomers, pharmacokinetic modelling and genotyping of the doxepin-metabolizing cytochrome P450 (CYP) enzymes led to the following conclusion: the lethal doxepin concentration of 2100ng/mL was more likely to have been reached due to drug interactions and genetic peculiarities leading to a reduction of the metabolic capacity and not by an acute (suicidal) overdose.
Source: Forensic Science International - Category: Forensic Medicine Authors: M.A. Neukamm, S. Vogt, M. Hermanns-Clausen, J. Naue, A. Thierauf, V. Auwärter Tags: Psychotropic drugs Source Type: research
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