A Tale of Two TrkA Inhibitor Trials: Same Target, Divergent Results

Nerve growth factor (NGF), a neurotrophin involved in the development of the nervous system, plays a key role in pain by sensitizing peripheral nociceptors following tissue injury or inflammation. This peripheral sensitization by NGF is mediated through binding to the high-affinity receptor tropomyosin-related kinase (Trk)A localized to peptidergic sensory nerves.1 The NGF-TrkA complex is internalized and transported to the dorsal root ganglion, where it increases TRPV1 phosphorylation and the expression and release of neuropeptides including substance P and calcitonin gene-related peptide.
Source: Osteoarthritis and Cartilage - Category: Rheumatology Authors: Tags: Editorial Source Type: research