Clinical and economic impact of generic versus brand name meropenem use in an intensive care unit in Colombia

Publication date: Available online 22 July 2019Source: The Brazilian Journal of Infectious DiseasesAuthor(s): Karen Ordóñez, Max M. Feinstein, Sergio Reyes, Cristhian Hernández-Gómez, Christian Pallares, María V. VillegasAbstractBackgroundRecent studies suggest that sustained use of generic antibiotics may be associated with clinical failure and emergence of antibacterial resistance. The present study was designed to determine the clinical outcome between the use of generic meropenem (GM) and brand-name meropenem (BNM). Additionally, this study evaluated the economic impact of GM and BNM to determine if the former represents a cost-effective alternative to the latter.MethodsPatients treated between January 2011 and May 2014 received GM while patients treated between June 2014 and March 2017 received BNM. Mortality was compared between groups. Total infection cost was defined by the cost of antimicrobial consumption, length of stay, and laboratory and imaging exams until infection resolution.FindingsA total of 168 patients were included; survival rate for the 68 patients treated with GM was 38% compared to 59% in the patients treated with BNM. Multivariate analysis showed that the variables most strongly-associated with mortality were cardiovascular disease (OR 18.18, 95% CI 1.25–262.3, p = 0.033) and treatment with generic meropenem (OR 18.45, 95% CI 1.45–232.32, p = 0.024). On the other hand, total infection cost did not...
Source: The Brazilian Journal of Infectious Diseases - Category: Infectious Diseases Source Type: research

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In this study, we genetically characterised Monogenea found on the gill of common carp in Iran. In total, 5603 parasites were recovered from 112 fish. The parasites were first identified morphologically as Dactylogyrus extensus, D. anchoratus, D. vastator, D. minutus, D. achmerowi and Gyrodactylus sprostonae. Representative samples were then subjected to sequencing. This is one of the first studies which has provided both morphological and sequence data for Dactylogyrus spp. and G. sprostonae. Our findings provide a foundation for future research into the genetic make-up of these economically significant parasites and the ...
Source: Parasitology International - Category: Parasitology Source Type: research
Publication date: Available online 22 August 2019Source: Advances in Virus ResearchAuthor(s): M. Alejandra Tortorici, David VeeslerAbstractCoronaviruses (CoVs) have caused outbreaks of deadly pneumonia in humans since the beginning of the 21st century. The severe acute respiratory syndrome coronavirus (SARS-CoV) emerged in 2002 and was responsible for an epidemic that spread to five continents with a fatality rate of 10% before being contained in 2003 (with additional cases reported in 2004). The Middle-East respiratory syndrome coronavirus (MERS-CoV) emerged in the Arabian Peninsula in 2012 and has caused recurrent outbre...
Source: Advances in Virus Research - Category: Virology Source Type: research
Publication date: Available online 23 August 2019Source: Zoologischer AnzeigerAuthor(s): Thalassa Matthews, Rachel Keeffe, David C. Blackburn
Source: A Journal of Comparative Zoology - Category: Zoology Source Type: research
Publication date: Available online 22 August 2019Source: Small Ruminant ResearchAuthor(s): Kalyan De, Shivendra Sharma, Pankaj Kumawat, Davendra Kumar, Palanisamy Thirumurugan, Artabandhu SahooAbstractIn the semi-arid tropical region, the winter is often associated with the cold wind. The physiology and production performance generally alter during winter in growing lambs. Therefore, the present study was initiated to assess the effect of wind protection during winter on growing lambs in a semi-arid tropical region. For this purpose, fourteen growing Malpura-cross lambs of 3-5 months of age with the body weight of 21.06&th...
Source: Small Ruminant Research - Category: Zoology Source Type: research
Publication date: Available online 22 August 2019Source: Veterinary MicrobiologyAuthor(s):
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: August 2019Source: Research in Veterinary Science, Volume 125Author(s):
Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research
The objective of the study was to (1) characterize and compare the chemical composition at the surface, subsurface and in the bulk of thin plastic films used for portosystemic shunt attenuation in their native state and after plasma exposure. (2) Assess the presence, concentration and location of irritant compounds (e.g dicetyl phosphate) within the films.Attenuated Total Reflectance Infrared Spectroscopy (ATR-IR), X-ray Photoelectron Spectroscopy (XPS) and dynamic Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) were used to analyze thirteen thin plastic films. Sample thickness was visualized and measured using S...
Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research
The objective of this study was to analyze the biochemical composition of the biomass of a native strain of S. subsalsa cultivated in low-cost saline medium and harvested in the expone...
Source: African Journal of Microbiology Research - Category: Microbiology Source Type: research
Publication date: September 2019Source: Journal of Microbiological Methods, Volume 164Author(s): Charlotte A. Huber, Valentin Pflüger, Sarah Reed, Kyra Cottrell, Hanna E. Sidjabat, Ama Ranasinghe, Hosam M. Zowawi, Patrick Harris, David L. PatersonAbstractIn our current study we were identifying 26 bacterial isolates using a SCIEX 5800 TOF/TOF MALDI instrument and an external database. The results were compared with the results of a Vitek® MS system and in case of discrepancies at the species level 16s rRNA sequencing was performed for further verification.
Source: Journal of Microbiological Methods - Category: Microbiology Source Type: research
Publication date: Available online 22 August 2019Source: Journal of Microbiological MethodsAuthor(s): Rodney Sebastian Hart, Neil Paul Jolly, Bongani Kaiser NdimbaAbstractThe wine yeast Saccharomyces cerevisiae forms an integral part of wine production by converting relatively ‘neutral’ flavoured grape must into varietal aromatic wines. Additionally, non-Saccharomyces strains can be used with S. cerevisiae for the production of wines with more complexity. Yeast strains, to varying extents, produce and/or mediate the release of a whole range of key metabolites, which in turn contribute to enhanced aroma and fl...
Source: Journal of Microbiological Methods - Category: Microbiology Source Type: research
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