More Evidence for Defects in the Formation of Autophagosomes to be Important in the Age-Related Decline of Autophagy

Autophagy is a collection of cellular maintenance processes that act to recycle damaged structures in the cell, thereby maintaining cell health and function. On the one hand, the efficiency of autophagy declines with age, and this loss of function is associated with numerous age-related diseases, particularly of the central nervous system and its population of very long-lived neurons. On the other hand, increased autophagy is an important component of many of the interventions shown to slow aging in short-lived species, such as via calorie restriction. A fair number of research groups are working on ways to upregulate autophagy in our species, but this has been going on for a while with little concrete movement towards the clinic. Autophagy is a complicated process of multiple steps, and at every step there are plausible proximate causes for a faltering of the system with age. The formation of autophagosomes to encapsulate materials to be recycled can break down, as is the case in today's open access paper. The mechanisms by which autophagosomes are transported to a lysosome for deconstruction of their contents are degraded. The lysosome itself becomes filled with metabolic waste that it struggles to break down, making it bloated and inefficient. In the case of defects relating to autophagosomes it is unclear as to why the breakage happens, how it relates to the underlying molecular damage that causes aging. Given this, approaches to therapy tend to focus on ove...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs

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Publication date: Available online 23 August 2019Source: Alzheimer's &DementiaAuthor(s): Carla M. Startin, Sarah Hamburg, Rosalyn Hithersay, Tamara Al-Janabi, Kin Y. Mok, John Hardy, Andre Strydom
Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Authors: Ma F, Lv X, Du Y, Chen H, Liu S, Zhao J, Gao Y, An P, Zhou X, Song A, Sun C, Wang G, Ji Y, Wang X, Xu W, Huang G Abstract BACKGROUND: Leukocyte telomere length (LTL) is associated with the aging process and age-related degenerative diseases. The relation of peripheral blood LTL to mild cognitive impairment (MCI) and Alzheimer's disease (AD) and the role of folate and homocysteine (Hcy) in this relation remain unclear. OBJECTIVES: We aimed to investigate the association between LTL and the risks of MCI/AD, and to explore whether folate and Hcy may play a role in this association. METHODS: This case-...
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
Authors: Li B, He Y, Ma J, Huang P, Du J, Cao L, Wang Y, Xiao Q, Tang H, Chen S Abstract OBJECTIVE: Gut microbiota changes before the onset of Alzheimer's disease (AD) and the alterations could be detected in the stage of mild cognitive impairment (MCI). The findings might offer diagnostic biomarkers before the onset of dementia. BACKGROUND: AD is the most common cause of dementia, and MCI is the predementia state. Recent studies suggest the alterations in the gut microbial communities associated with AD, whereas the microbiota in MCI before the onset of dementia has not been discovered and characterized in hum...
Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
Publication date: Available online 22 August 2019Source: NeuroImageAuthor(s): Eunho Lee, Jun-Sik Choi, Minjeong Kim, Heung-Il Suk, the Alzheimer's Disease Neuroimaging InitiativeAbstractIn this paper, we propose a novel method for magnetic resonance imaging based Alzheimer's disease (AD) or mild cognitive impairment (MCI) diagnosis that systematically integrates voxel-based, region-based, and patch-based approaches into a unified framework. Specifically, we parcellate the brain into predefined regions based on anatomical knowledge (i.e., templates) and derive complex nonlinear relationships among voxels, whose intensities ...
Source: NeuroImage - Category: Neuroscience Source Type: research
On average, family members spend nearly 22 hours each week caring for parents, grandparents and siblings with Alzheimer's and other conditions. But a new intervention may give them back some of those lost sleep hours.
Source: Health News - UPI.com - Category: Consumer Health News Source Type: news
We examined two separate cohorts (N = 126; N = 112) of cognitively normal controls, early and late mild cognitive impairment (MCI), and Alzheimer's disease. Demographic, clinical, diffusion-weighted and T1-weighted imaging, and positron emission tomography (PET) imaging were assessed. Results indicated elevated hippocampal free-water in early MCI individuals compared to controls across both cohorts. In contrast, there was no difference in volume of these regions between controls and early MCI. ADNI free-water values in the hippocampus was associated with low CSF AB1–42 levels and high global amyloid PET value...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
ConclusionsThis is the first report about the evaluation of AChE inhibitory activity and phytochemical profiles of D. auriculatum, led to the identification of 36 compounds including alkaloids and flavonoids, and five alkaloids exhibited a significant AChE inhibitory activity and had the potential as AChE inhibitors. This study provided scientific experimental basis for the traditional efficacy of neurological disease of the plant.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSION: Our results suggest that downregulation of kdm4a expression may be a potential therapeutic target in AD. PMID: 31436053 [PubMed - in process]
Source: J Korean Med Sci - Category: General Medicine Authors: Tags: J Korean Med Sci Source Type: research
Scientists worldwide engaged in research to develop a biomarker for dementia are predicting success, though some say additional research will be needed Could a blood test for Alzheimer’s disease soon be on clinical laboratory test menus nationwide? Perhaps so. A recent Associated Press (AP) article that was picked up by NBC News and other healthcare […]
Source: Dark Daily - Category: Laboratory Medicine Authors: Tags: Instruments & Equipment Laboratory Instruments & Laboratory Equipment Laboratory News Laboratory Pathology Laboratory Testing Alzheimer’s disease anatomic pathology Brian Gordon PhD clinical laboratory CT Dark Daily dark intelligen Source Type: news
ACS Chemical NeuroscienceDOI: 10.1021/acschemneuro.9b00329
Source: ACS Chemical Neuroscience - Category: Neuroscience Authors: Source Type: research
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