Analysis of gene mutation characteristics in patients with chronic neutrophilic leukaemia.

Conclusion and Discussion: CSF3R mutation is the main tumorigenic mutation in CNL, in which CSF3R T618I mutation is the main mutation, and an extremely small number of CNL patients may be caused by JAK2 V617F mutation. SETBP1 and ASXL1 are the most common concomitant mutations in CNL with CSF3R mutation, and SETBP1 and CSF3R T618Imutations may have a certain correlation. PMID: 31315541 [PubMed - in process]
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research