Distinct immune response profile during Rhipicephalus (Boophilus) microplus infestations of Guzerat dairy herd according to the maternal lineage ancestry (mitochondrial DNA)

Publication date: Available online 19 July 2019Source: Veterinary ParasitologyAuthor(s): Fernanda Fortes de Araújo, Juliano Bergamo Ronda, Eustáquio Resende Bittar, Guilherme Costa Venturini, Guilherme Caetano Garcia, Olindo Assis Martins-Filho, Márcio Sobreira Silva Araújo, Joely Ferreira Figueiredo BittarAbstractRhipicephalus (Boophilus) microplus ticks cause major constraints to public and livestock health, and serious economic losses. It is well known that the immune response to infestations with cattle ticks is influenced by the host genetic background leading to distinct immunological profiles between bovine hosts genetically susceptible and resistant. The influence of Bos indicus (Bi) and Bos taurus (Bt) maternal lineage ancestry of mitochondrial DNA in the profile of the immune response of Zebu cattle to ticks remains unknown. The present work evaluated the hematological parameters and the immune response profile in the peripheral blood of a Guzerat dairy herd, further categorized into two maternal lineage ancestry subgroups (Bi-mtDNA and Bt-mtDNA) after experimental infestation with larvae of R. microplus. Our data demonstrated that although hematological and erythrogram analysis showed a similar profile throughout, some cell populations present a distinct profile between the groups. Especially MON, CD335+ and CD8+ T-cells are predominant in Bi-mtDNA. Moreover, an overall picture of R. microplus infestation demonstrated that Bi-mtDNA presented a more efficient an...
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research