Extracellular vesicles as novel diagnostic and research tool for patients with HTN and Kidney disease.

Extracellular vesicles as novel diagnostic and research tool for patients with HTN and Kidney disease. Am J Physiol Renal Physiol. 2019 Jul 17;: Authors: Erdbruegger U, Le TH Abstract Hypertension (HTN) affects one in three adults in the US and is a major risk factor for cardiovascular disease (CVD) and kidney failure. There is emerging evidence that more intense blood pressure (BP) lowering reduces mortality in patients with kidney disease who are at risk of CVD and progression to end-stage renal disease. However, the ideal blood pressure threshold for patients with kidney disease remain a question of debate and controversy. Novel tools to more precisely diagnose HTN, tailor treatment and predict risk of end organ damage such as kidney disease are needed. Analysis of circulating and urinary extracellular vesicles (EVs) and its cargo (protein and RNA) has the potential to identify novel non-invasive biomarkers which can also reflect specific pathologic mechanism of different HTN phenotypes. We will discuss use of EVs as markers of HTN severity, explain their profile change with antihypertensive medicine and potential to detect early end organ damage. However, more studies with enhanced rigor in this field are needed to define the BP threshold to prevent or delay kidney disease progression and decrease cardiovascular risk. PMID: 31313949 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Renal Physiology - Category: Physiology Authors: Tags: Am J Physiol Renal Physiol Source Type: research