Mitigation of Murine Focal Cerebral Ischemia by the Hypocretin/Orexin System is Associated With Reduced Inflammation [Basic Sciences]

Conclusions—
Loss of Hcrt neurons in AT mice resulted in worsened stroke outcomes, which were reversed by administration of exogenous Hcrt-1. The mechanism underlying Hcrt-mediated neuroprotection includes attenuation of inflammatory responses after ischemic insult.

Source: Stroke - February 25, 2013 Category: Neurology Authors: Xiong, X., White, R. E., Xu, L., Yang, L., Sun, X., Zou, B., Pascual, C., Sakurai, T., Giffard, R. G., Xie, X. Tags: Ischemic biology - basic studies, Behavioral Changes and Stroke, Neuroprotectors Basic Sciences Source Type: research