Common Variants Within Oxidative Phosphorylation Genes Influence Risk of Ischemic Stroke and Intracerebral Hemorrhage [Clinical Sciences]

Conclusions— This pathway analysis demonstrates association between common genetic variants within OXPHOS genes and stroke. The associations for small vessel stroke and deep ICH suggest that genetic variation in OXPHOS influences small vessel pathobiology. Further studies are needed to identify culprit genetic variants and assess their functional consequences.

http://stroke.ahajournals.org/cgi/content/short/44/3/612?rss=1

Source: Stroke - February 25, 2013 Category: Neurology Authors: Anderson, C. D., Biffi, A., Nalls, M. A., Devan, W. J., Schwab, K., Ayres, A. M., Valant, V., Ross, O. A., Rost, N. S., Saxena, R., Viswanathan, A., Worrall, B. B., Brott, T. G., Goldstein, J. N., Brown, D., Broderick, J. P., Norrving, B., Greenberg, S. M Tags: Acute Cerebral Hemorrhage, Acute Cerebral Infarction, Brain Circulation and Metabolism, Genetics of Stroke Clinical Sciences Source Type: research