Increased Renal Cellular Senescence in Murine High-fat Diet: Effect of the Senolytic Drug Quercetin

Obesity and dyslipidemia can be associated with cellular senescence, and may impair kidney function. However, whether senescence contributes to renal dysfunction in these conditions remains unclear. Quercetin is an abundant dietary flavonoid that selectively clears senescent cells by inhibiting PI3K/AKT and p53/p21/serpines and inducing apoptosis. We hypothesized that high-fat-diet-induced obesity causes renal senescence, which would be mitigated by quercetin. Methods: C57BL/6J mice fed either standard chow or high-fat diets were treated with quercetin (50mg/kg) or vehicle 5-days biweekly via oral gavage for 10-weeks.

Source: Translational Research - July 14, 2019 Category: Research Authors: Seo Rin Kim, Kai Jiang, Mikolaj Ogrodnik, Xiaojun Chen, Xiang-Yang Zhu, Hannah Lohmeier, Leena Ahmed, Hui Tang, Tamara Tchkonia, LaTonya J. Hickson, James L. Kirkland, Lilach O. Lerman Source Type: research