Chemical composition, antimicrobial, modulator and antioxidant activity of essential oil of Dysphania ambrosioides (L.) Mosyakin & Clemants.

Chemical composition, antimicrobial, modulator and antioxidant activity of essential oil of Dysphania ambrosioides (L.) Mosyakin & Clemants. Comp Immunol Microbiol Infect Dis. 2019 Aug;65:58-64 Authors: Almeida Bezerra JW, Rodrigues Costa A, de Freitas MA, Rodrigues FC, de Souza MA, da Silva ARP, Dos Santos ATL, Vieiralves Linhares K, Melo Coutinho HD, de Lima Silva JR, Bezerra Morais-Braga MF Abstract The oil presented the α-Terpinene as the major compound with 54.09% presence. Antibacterial activity demonstrated significant MIC against Staphylococcus aureus (256 μg/mL) and moderate against Pseudomonas aeruginosa (512 μg/mL). The modulating effect of antibiotics was significant against P. aeruginosa potentiating the effect of all the antibiotics tested. The IC50 observed for CT LM 23 was clinically relevant (19.3 μg/mL), similar to that obtained for CA INCQS 40006 (25.2 μg/mL). The combined effect with fluconazole also showed significant results, 0.1 and 22.7 μg/mL, for CT LM 23 and CA INCQS 40006, respectively. For CA LM 77 the IC50 was 101.9 μg/mL and for CT INCQS 40042 a value of 53.3 μg/mL. Regarding the modulation, both were considered of clinical relevance, 3.3 and 6.4 μg/mL. OEDA has low antioxidant activity (>1024 μg/mL). Therefore, the popular use against infections was corroborated by this work. PMID: 31300127 [PubMed - in process]
Source: Comparative immunology, microbiology and infectious diseases. - Category: Allergy & Immunology Authors: Tags: Comp Immunol Microbiol Infect Dis Source Type: research