Hyponatremia in children under 100  days old: incidence and etiologies

Conclusion: Our findings confirm that hyponatremia is a frequent electrolyte disorder in neonates. Various mechanisms underlie this condition, most of which could be prevented by optimized management. The prevalence of genetic hypoaldosteronism and pseudohypoaldosteronism was higher than expected. We provide a simple diagram to help physicians identify the mechanisms underlying neonatal hyponatremia.What is Known:•In neonates, hyponatremia may be multifactorial, making it difficult to treat.•Newborns display partial resistance to aldosterone, and preterms have a defect in aldosterone secretion.What is New:•Four percent of hospitalized neonates had hyponatremia, 86% hospital-acquired. Hyponatremia was due to a transient or constitutional defect of the mineralocorticoid pathway in 26/86 patients (30%) which is higher than expected.•We propose a tree diagram for improving the management of hyponatremia in neonates.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research