A phase I study of the safety and tolerability of VLX600, an Iron Chelator, in patients with refractory advanced solid tumors

Conclusion VLX600 was reasonably well tolerated and, together with preclinical data, there is support for further efforts to explore its activity as single agent and in combination with drugs or radiation.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research

Related Links:

CONCLUSION: This first randomized resistance training trial in pancreatic cancer patients indicated clinically relevant improve- ments in QoL after 3 but not after 6 months. Given the severity of pancreatic cancer, exercise recommendations may already commence at surgery. PMID: 31431236 [PubMed - in process]
Source: Deutsches Arzteblatt International - Category: General Medicine Tags: Dtsch Arztebl Int Source Type: research
This study demonstrates that model C1 is able to predict the 1,1,1-TCA breakthrough time and rapidly evaluate the Bio-PRBs retardation performance. The results show that microbial growth and immobilization are the key factors that affect the retardation and remediation performance of Bio-PRBs. The free growth of microorganisms had significant negative effects on hydraulic conductivity (K) in the zero-valent iron (ZVI) region of free microorganism Bio-PRBs (FM-PRBs). The total head loss in the FM-PRB was 9.0 cm, which was significantly greater than the head loss (6.5 cm) of immobilized microorganism Bio-PRBs (IM-PRBs). ...
Source: Environmental Pollution - Category: Environmental Health Authors: Tags: Environ Pollut Source Type: research
Discussion and conclusions: Deferasirox does not appear to be well tolerated in SCD patients older than 40 years, in which complications of the underlying disease are already fully installed. The choice of the ideal iron chelator for this population should include an evaluation of comorbidities and organic dysfunctions, as well as the need to find pharmacogenetic safety markers in this group of patients. PMID: 31434554 [PubMed - in process]
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research
AbstractThe various environmental ill effects from manufacturing of cement have provoked research into the advancement of concrete using a 100% replacement material by activated alkali solutions. Geopolymer concrete is an eco-friendly binder, which has attained significant attention among the researchers worldwide in past few decades. Large quantity of industrial waste ash is generated by thermal power plant, mining industry, timber industry, rice milling industry, steel and iron industry, etc. which have posed the industries a great threat when it comes to the disposal of these waste ash due to the various ill effects on ...
Source: European Journal of Applied Physiology - Category: Physiology Source Type: research
In conclusion, the PRPF4 gene plays an important role in the growth of breast cancer cells and is therefore a potential therapeutic target.
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
Publication date: 15 December 2019Source: Journal of Molecular Structure, Volume 1198Author(s): Lei Wang, Gui-Bin XueAbstractSolvothermal reactions of 1, 3, 5-tris (4-carboxyphenyl)-benzene (H3BTB) with Gd(NO3)·6H2O gave rise to a new highly porous coordination polymer {[Gd(BTB)(H2O)](DMF)(H2O)}n (1) having three dimensional structure. In light of its highly rigid framework as well as the large one-dimensional triangular channel configuration that has abundant open metal sites, we can utilize the resulting activated 1a as effective Lewis catalysts for the acetaldehyde's cyanosilylation at room temperature. The compa...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: 15 December 2019Source: Journal of Molecular Structure, Volume 1198Author(s): Liji John, Arish Dasan, R. Selwin Joseyphus, I. Hubert JoeAbstractCo(II), Ni(II), Cu(II) and Zn(II) complexes of Schiff base ligand (thio-L-his) derived from thiophene-2-carboxaldehyde (thio) with l-histidine (L-his) were synthesised. The thio-L-his and its metal complexes have been optimized and quantum chemical parameters are calculated using density functional theory. Despite several donor sites in the synthesised thio-L-his, the coordination with metal ion occurred through azomethine nitrogen and carboxylate oxygen as eviden...
Source: Journal of Molecular Structure - Category: Molecular Biology Source Type: research
Publication date: Available online 20 August 2019Source: Journal of Molecular LiquidsAuthor(s): Sadegh Farhadian, Behzad Shareghi, Farhang Tirgir, Somayeh Reiisi, Neda Gholamian Dehkordi, Lida Momeni, Ehsan HeidariAbstractOver the past decades, anti-cancer drugs consist of cytotoxic drugs have been interested and developed. Despite the great advances in chemotherapy, there is still no certain medical treatment for cancer. During this investigation, a novel 2,5-diketopiperazine derivative 3(R),6(S)-bis (4-hydroxy phenyl)-piperazine-2,5-dione: (BHPPD) was designed, synthesized, and evaluated. The effects on intestinal protea...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Publication date: 15 November 2019Source: Journal of Molecular Liquids, Volume 294Author(s): Georgiana-Oana Turcan-Trofin, Mirela-Fernanda Zaltariov, Gheorghe Roman, Sergiu Shova, Nicoleta Vornicu, Mihaela Balan-Porcarasu, Dragos Lucian Isac, Andrei Neamtu, Maria CazacuAbstractPairs of different substituted 3-mercapto-1,2,4-triazole units are coupled, through thioether bridges, to organic-inorganic substrates consisting in short hydrophobic silicone segment. A library of six compounds are isolated as crystalline solids and structurally characterized by X-ray single crystal diffraction, elemental, spectral and thermal analy...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
Publication date: 1 November 2019Source: Journal of Molecular Liquids, Volume 293Author(s): Jing Zhang, Ruijuan Li, Guanghui Ding, Yingying Wang, Chunchao WangAbstractIn the present study, magnetic multi-walled carbon nanotubes (MMWCNTs), magnetic single-walled carbon nanotubes (MSWCNT) and magnetic graphene nanosheets (MGNS) were prepared and the sorptive removal of phenanthrene from water by them was investigated. TEM analysis showed that carbon nanomaterials (CNMs) were coated with iron oxide nanoparticles, which were proved by Fourier transform infrared spectrometer. Magnetism determination also confirmed the formation...
Source: Journal of Molecular Liquids - Category: Molecular Biology Source Type: research
More News: Anemia | Cancer | Cancer & Oncology | Constipation | Drugs & Pharmacology | Investigational New Drugs | Iron | Mitochondrial Disease | Pulmonary Thromboembolism | Study