Molecules, Vol. 24, Pages 2525: Endlicheria bracteolata (Meisn.) Essential Oil as a Weapon Against Leishmania amazonensis: In Vitro Assay

Molecules, Vol. 24, Pages 2525: Endlicheria bracteolata (Meisn.) Essential Oil as a Weapon Against Leishmania amazonensis: In Vitro Assay Molecules doi: 10.3390/molecules24142525 Authors: Mariana Margatto Rottini Ana Claudia Fernandes Amaral José Luiz Pinto Ferreira Edinilze Souza Coelho Oliveira Jefferson Rocha de Andrade Silva Noemi Nosomi Taniwaki Arith Ramos dos Santos Fernando Almeida-Souza Celeste da Silva Freitas de Souza Kátia da Silva Calabrese The difficulties encountered and the numerous side effects present in the treatment of cutaneous leishmaniasis have encouraged the research for new compounds that can complement or replace existing treatment. The growing scientific interest in the study of plants, which are already used in folk remedies, has led our group to test Endlicheria bracteolata essential oil against Leishmania amazonensis. Several species of the Lauraceae family, or their compounds, have relevant antiprotozoal activities Therefore, the biological potential on L. amazonensis forms from the essential oil of Endlicheria bracteolata leaves was verified for the first time in that work. The antileishmanial activity was evaluated against promastigotes and intracellular amastigotes, and cytotoxicity were performed with J774.G8, which were incubated with different concentrations of E. bracteolata essential oil. Transmission electron microscopy and flow cytometry were performed with E. bracteolata essential oil IC50. Promastigote for...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research