Molecules, Vol. 24, Pages 2500: Anti-Multiple Myeloma Potential of Secondary Metabolites from Hibiscus sabdariffa
Molecules, Vol. 24, Pages 2500: Anti-Multiple Myeloma Potential of Secondary Metabolites from Hibiscus sabdariffa
Molecules doi: 10.3390/molecules24132500
Authors:
Alessio Malacrida
Valeria Cavalloro
Emanuela Martino
Arianna Cassetti
Gabriella Nicolini
Roberta Rigolio
Guido Cavaletti
Barbara Mannucci
Francesca Vasile
Marcello Di Giacomo
Simona Collina
Mariarosaria Miloso
Multiple myeloma (MM) belongs to hematological cancers and its incidence is increasing worldwide. Despite recent advances in its therapy, MM still causes many deaths every year. In fact, current therapies sometimes fail and are associated with severe adverse effects, including neurotoxicity. As a part of our ongoing efforts to discover new potential therapies against MM, we prepared Hibiscus sabdariffa extracts obtained by a microwave-assisted solvent extraction and investigate their activity by in vitro assays on the RPMI-8226 cell line. The bioguided fractionation of the crude ethanolic extract allowed the identification of HsFC as the most effective extract. We assessed cell viability (MTT and Tripan blue test), cell migration (Boyden chamber assay), and neurotoxicity (DRG neurotoxicity assay). The promising results prompted us to further fractionate HsFC and we obtained two molecules effective against RPMI-8226 cells without neurotoxic effects at their active concentrations. Moreover, both compounds are able to significantly reduce cell migration.
Source: Molecules - Category: Chemistry Authors: Alessio Malacrida Valeria Cavalloro Emanuela Martino Arianna Cassetti Gabriella Nicolini Roberta Rigolio Guido Cavaletti Barbara Mannucci Francesca Vasile Marcello Di Giacomo Simona Collina Mariarosaria Miloso Tags: Article Source Type: research
More News: Brain | Cancer | Cancer & Oncology | Chemistry | Hematology | Hibiscus | Myeloma | Neurology