Lateral Antebrachial Cutaneous Nerve as Autologous Graft for Mini-Invasive Corneal Neurotization (MICORNE)

Conclusions: We report the first case of MICORNE, a novel surgical technique of corneal neurotization in a herpetic patient with NK. Despite the potential risk of viral recurrence, our patient showed dramatic improvement in corneal sensation and visual acuity.
Source: Cornea - Category: Opthalmology Tags: Case Report Source Type: research

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Conclusions: Important associations exist between PHG and family history of PHG, psychiatric history, supplement use, and vitamin deficiencies, providing insight into the pathophysiology and potential comorbidities of PHG.
Source: International Journal of Trichology - Category: Dermatology Authors: Source Type: research
Authors: Mancuso R, Sicurella M, Agostini S, Marconi P, Clerici M Abstract Introduction: Alzheimer's disease (AD), the most common form of dementia worldwide, is a multifactorial disease with a still unknown etiology. Herpes simplex virus 1 (HSV-1) has long been suspected to be one of the factors involved in the pathogenesis of the disease. Areas covered: We review the literature focusing on viral characteristics of HSV-1, the mechanisms this virus uses to infect neural cells, its interaction with the host immune system and genetic background and summarizes results and research that support the hypothesis of an ass...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
Viruses, Vol. 11, Pages 756: Herpes Simplex Virus Type 1–Encoded miR-H2-3p Manipulates Cytosolic DNA–Stimulated Antiviral Innate Immune Response by Targeting DDX41 Viruses doi: 10.3390/v11080756 Authors: Yongzhong Duan Jieyuan Zeng Shengtao Fan Yun Liao Min Feng Lichun Wang Ying Zhang Qihan Li Herpes simplex virus type 1 (HSV-1), one of the human pathogens widely epidemic and transmitted among various groups of people in the world, often causes symptoms known as oral herpes or lifelong asymptomatic infection. HSV-1 employs many sophisticated strategies to escape host antiviral immune respo...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
In conclusion, we for the first time identified circRNA-miRNA-mRNA network from P. olivaceus in the pathogenesis of E. tarda, and provided valuable resources for further analyses of the molecular mechanisms and signaling networks.
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
Publication date: Available online 12 August 2019Source: Research in Veterinary ScienceAuthor(s): Gianvito Lanave, Maria S. Lucente, Pietro Siciliano, Claudia Zizzadoro, Paolo Trerotoli, Vito Martella, Canio Buonavoglia, Maria Tempesta, Michele CameroAbstractCaprine alphaherpesvirus 1 (CpHV-1) induces genital lesions in its natural host similar to those caused by Human alphaherpesvirus 2 (HHV-2), commonly named herpes simplex virus 2 (HSV-2) in human patients. CpHV-1 infection in goats could represent a useful homologous animal model for the study of HSV-2 infection, chiefly for the assessment of antiviral drugs in in vivo...
Source: Research in Veterinary Science - Category: Veterinary Research Source Type: research
Karel Šmejkal Javier Echeverría Psoromic acid (PA), a bioactive lichen-derived compound, was investigated for its inhibitory properties against herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), along with the inhibitory effect on HSV-1 DNA polymerase, which is a key enzyme that plays an essential role in HSV-1 replication cycle. PA was found to notably inhibit HSV-1 replication (50% inhibitory concentration (IC50): 1.9 μM; selectivity index (SI): 163.2) compared with the standard drug acyclovir (ACV) (IC50: 2.6 μM; SI: 119.2). The combination of PA with ACV has led to potent inhibi...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
ConclusionThe new HSV-1 based platform described provides a potent and versatile approach to developing new oncolytic immunotherapies for clinical use. Each of the modifications employed was demonstrated to aid in optimizing the potential of the virus to both directly kill tumors and to lead to systemic therapeutic benefit. For clinical use, these viruses are expected to be most effective in combination with other anti-cancer agents, in particular PD1/L1-targeted immune checkpoint blockade. The first virus from this program (expressing GALV-GP-R− and hGM-CSF) has entered clinical development alone and in combination ...
Source: Journal for Immunotherapy of Cancer - Category: Cancer & Oncology Source Type: research
Authors: Thitiwichienlert S, Leeamornsiri S PMID: 31389219 [PubMed - in process]
Source: Korean Journal of Ophthalmology : KJO - Category: Opthalmology Tags: Korean J Ophthalmol Source Type: research
This study is the first to assess the efficacy of FIT039 and will contribute to the development of antiviral agents that can cure refractory common warts in immunocompromised patients.Trial registrationUMIN Clinical Trials,UMIN000029695. Registered on 1 November 2017.
Source: Trials - Category: Research Source Type: clinical trials
Conclusions: We successfully performed an unprecedented genetic analysis of an HSV-1 strain isolated from a case of bilateral necrotizing HSK in an immunocompetent patient. The association of the HSV-1 genotype with the clinical manifestation remains unclear, calling for more data from new cases, especially from different geographic regions.
Source: Cornea - Category: Opthalmology Tags: Case Report Source Type: research
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