The epigenetic regulator SIRT6 protects the liver from alcohol-induced tissue injury by reducing oxidative stress in mice

Chronic and excessive alcohol consumption causes nearly half of liver cirrhosis-associated mortality in the United States, but there remains no effective treatment for the underlying liver disorder [1]. An early stage of alcohol-related liver disease (ALD), which is featured as simple hepatic steatosis, is reversible; however, chronic and excessive alcohol consumption can lead to progressive steatohepatitis (ASH) and fibrosis, and in some cases, the disease further progresses to cirrhosis and even hepatocellular carcinoma [2,3].

Source: Journal of Hepatology - July 7, 2019 Category: Gastroenterology Authors: Hyeong Geug Kim, Menghao Huang, Yue Xin, Yang Zhang, Xinge Zhang, Gaihong Wang, Sheng Liu, Jun Wan, Ali Reza Ahmadi, Zhaoli Sun, Suthat Liangpunsakul, Xiwen Xiong, Xiaocheng Charlie Dong Source Type: research