Chronic administration of phenytoin induces efflux transporter overexpression in rats.

CONCLUSIONS: Overexpression of efflux transporters can be mediated by inducer agents like PHT in a local-concentration dependent manner, and it is reversible once the substance is removed from the body. The recovery of basal Pgp expression could allow the design of dosing schedules that optimize anticonvulsant therapy.
PMID: 25443719 [PubMed - in process]

Source: Pharmacological Reports - December 1, 2014 Category: Drugs & Pharmacology Authors: Alvariza S, Fagiolino P, Vázquez M, Feria-Romero I, Orozco-Suárez S Tags: Pharmacol Rep Source Type: research